大豆卵磷脂碳量子点的光学性能及基因凝聚性能研究  

Optical Properties and Gene Condensation Properties of Carbon Quantum Dots Produced from Soybean Lecithin

作　　者：于子淇 董荣千 刘佳茗 程振原 王安心 黄宗岱 刘翔 赵海洋 孙婉 Yu Ziqi;Dong Rongqian;Liu Jiaming;Cheng Zhenyuan;Wang Anxin;Huang Zongdai;Liu Xiang;Zhao Haiyang;Sun Wan(College of Medicine and Nursing,Dezhou University,Dezhou 253023,China)

机构地区：[1]德州学院医药与护理学院,山东德州253023

出　　处：《山东化工》2024年第13期13-16,21,共5页Shandong Chemical Industry

基　　金：德州学院博士启动基金(2019xjrc335);大学生创新创业训练项目(S202310448098)。

摘　　要：碳量子点因良好的光稳定性和低毒性在生物医学领域得到广泛应用,天然的碳源因其成本低、环境友好被广泛用于碳量子点的制备。利用大豆卵磷脂作为碳源通过水热法合成一种大豆卵磷脂基碳量子点。大豆卵磷脂作为一种天然的磷脂具有良好的药物递送能力,既充当碳源又充当阳离子化剂。通过添加三苯基磷增强其正电性,生成的碳量子点表现出强而稳定的荧光,与未添加三苯基磷组相比,该碳点的尺寸为5 nm,zeta电位为35.8 mV,在与DNA质量比为800∶1时,完全凝聚DNA,具有潜在的DNA递送能力。Carbon quantum dots(CQDS)are widely used in the biomedical field because of their good photo stability and low toxicity.Natural carbon sources are widely used in the preparation of carbon quantum dots because of their low cost and environmental friendliness.A soybean lecithin based carbon quantum dot was synthesized by hydrothermal method using soybean lecithin as carbon source.As a natural phospholipid,soybean lecithin has good drug delivery ability,acting as both a carbon source and a cationizing agent.By adding triphenylphosphorus to enhance its positive electrical properties,the resulting carbon quantum dots showed strong and stable fluorescence,compared with the group without triphenylphosphorus,the size of the carbon quantum dots was 5 nm,the zeta potential was 35.8 mV,and complete condense DNA at a mass ratio of 800∶1 to DNA,which prove that soybean lecithin based carbon quantum dots have potential gene delivery ability.

关 键 词：碳量子点 大豆卵磷脂 光学性质 基因凝聚 

分 类 号：TQ127.1[化学工程—无机化工]