血清GSP、HbA1c、IGF-1水平与妊娠期糖尿病患者妊娠结局的相关性及其联合检测对不良妊娠结局的早期预测价值  

Correlation of serum GSP,HbA1c,IGF-1 levels with pregnancy outcomes in patients with gestational diabetes mellitus and the value of combined detection for early prediction of adverse pregnancy outcomes

作　　者：连娇 刘静 李洋 Lian Jiao;Liu Jing;Li Yang(Department of Obstetrics and Gynecology,Xinzheng Huaxin People's Hospital,Xinzheng 451100,Henan,China)

机构地区：[1]新郑华信民生医院妇产科,河南新郑451100

出　　处：《四川生理科学杂志》2024年第7期1473-1476,共4页

基　　金：河南省医学科技攻关联合共建项目(LHGJ20206019)。

摘　　要：目的:探讨血清糖化血清蛋白(Glycosylated serum protein,GSP)、糖化血红蛋白(Glycated hemoglobin A1c,HbA1c)、胰岛素样生长因子1(Insulin-like growth factors-1,IGF-1)水平与妊娠期糖尿病(Gestational diabetes mellitus,GDM)患者妊娠结局的相关性,及其联合检测对不良妊娠结局的预测价值。方法:选取2021年5月至2023年5月新郑华信民生医院收治的127例孕24~28 w的确诊GDM患者作为研究对象的GDM组,另选取同期孕期检查的127例孕24~28 w健康孕妇作为研究对象的正常对照组。比较GDM组和正常对照组入组时血清GSP、HbA1c、IGF-1水平;根据妊娠结局将127例GDM患者分为不良妊娠结局和良好妊娠结局,比较不良妊娠结局GDM患者和良好妊娠结局GDM患者入组时血清GSP、HbA1c、IGF-1水平;分析入组时血清GSP、HbA1c、IGF-1水平与GDM患者不良妊娠结局的相关性。分析入组时血清GSP、HbA1c、IGF-1水平联合检测对GDM患者不良妊娠结局的早期预测价值。结果:GDM组入组时血清GSP、HbA1c水平高于正常对照组,血清IGF-1水平低于正常对照组(P<0.05)。不良妊娠结局GDM患者入组时血清GSP、HbA1c水平高于良好妊娠结局者,血清IGF-1水平低于良好妊娠结局者(P<0.05);入组时血清GSP、HbA1c水平与不良妊娠结局呈正相关,血清IGF-1水平与不良妊娠结局呈负相关(P<0.05)。入组时血清GSP、HbA1c、IGF-1水平联合检测预测GDM患者不良妊娠结局的曲线下面积(Area under curve,AUC)为0.872,高于各项指标单独检测的0.738、0.776、0.723(P<0.05)。结论:入组时血清GSP、HbA1c、IGF-1水平与GDM患者不良妊娠结局的发生密切相关,其联合检测可作为临床早期预测GDM患者不良妊娠结局的血清学指标。Objective:To investigate the correlation of serum glycosylated serum protein(GSP),glycated hemoglobin A1c(HbA1c),insulin-like growth factor-1(IGF-1)with pregnancy outcomes in patients with gestational diabetes mellitus(GDM),and the predictive value of combined detection for adverse pregnancy outcomes.Methods:A total of 127 GDM patients diagnosed at 24-28 weeks of gestation admitted to Xinzheng Huaxin People's Hospital from May 2021 to May 2023 were selected as the GDM group,and 127 healthy pregnant women examined at 24-28 weeks of gestation during the same period were selected as the normal control group.Serum of GSP,HbA1c and IGF-1 levels were compared between GDM group and normal control group.According to pregnancy outcomes,127 GDM patients were divided into poor pregnancy outcomes and good pregnancy outcomes.Serum GSP,HbA1c and IGF-1 levels were compared between GDM patients with poor pregnancy outcomes and good pregnancy outcomes.The correlation of serum GSP,HbA1c,IGF-1 levels with adverse pregnancy outcomes in GDM patients was analyzed.The combined detection value of serum GSP,HbA1c and IGF-1 levels in the early prediction of adverse pregnancy outcomes in GDM patients was analyzed.Results:The serum levels of GSP and HbA1c in GDM group were higher than those in normal control group,and the serum level of IGF-1was lower than that in normal control group(P<0.05).The serum levels of GSP and HbA1c in GDM patients with adverse pregnancy outcome were higher than those in good pregnancy outcome,and the serum level of IGF-1 was lower than that in good pregnancy outcome(P<0.05).Serum levels of GSP and HbA1cwere positively correlated with adverse pregnancy outcomes,while serum level of IGF-1 was negatively correlated with adverse pregnancy outcomes(P<0.05).The area under curve(AUC)combined detection of serum levels of GSP,HbA1c and IGF-1 predicting adverse pregnancy outcomes of GDM patients was 0.872,which was higher than the above indicators alone 0.738,0.776 and 0.723(P<0.05).Conclusion:The serum levels of GSP,HbA1c

关 键 词：妊娠期糖尿病 妊娠结局 糖化血清蛋白 糖化血红蛋白 胰岛素样生长因子1 

分 类 号：R714.256[医药卫生—妇产科学]