沙丁胺醇与西替利嗪联合治疗过敏性咳嗽患儿对免疫球蛋白及相关细胞因子水平的影响  

Effects of salbutamol combined with cetirizine on the levels of immunoglobulin and related cytokines in children with allergic cough

作　　者：方圆 马威[2] 贾沛生[2] Fang yuan;Ma Wei;Jia Pei-sheng(The Affiliated Hospital of Xinyang Vocational and Technical College,Xinyang 464000,Henan,China;PICU,The First Affiliated Hospital of Zhengzhou University,Xinyang 464000,Henan,China)

机构地区：[1]信阳职业技术学院附属医院,河南信阳464000 [2]郑州大学第一附属医院PICU,河南信阳464000

出　　处：《四川生理科学杂志》2024年第7期1493-1496,共4页

摘　　要：目的:探讨沙丁胺醇与西替利嗪联合治疗方案在过敏性咳嗽患者中的应用效果。方法:选取2021年12月~2024年2月本院收治的120例过敏性咳嗽患儿作为研究对象,通过随机数字表法分为参考组和实验组,各60例。参考组患儿口服西替利嗪治疗;实验组患儿在对照组基础上增加口服沙丁胺醇治疗,两组均持续用药2 w。观察两组免疫球蛋白、炎性因子水平、咳嗽症状及不良反应发生情况。结果:两组治疗后的血清免疫球蛋白G(Immunoglobulin G,IgG)、免疫球蛋白A(Immunoglobulin A,IgA)和免疫球蛋白G(Immunoglobulin M,IgM)水平均高于治疗前,且实验组较参考组高(P<0.05);两组治疗后的血清白细胞介素-6(Interleukin-6,IL-6)和肿瘤坏死因子-α(Tumor necrosis factor-α,TNF-α)水平较之治疗前均更低,但两组间无明显差异(P>0.05);较之治疗前,两组治疗后的咳嗽症状各项积分均更低,且实验组低于参考组(P<0.05);两组患儿不良反应总发生率无明显差异(P>0.05)。结论:沙丁胺醇与西替利嗪联合治疗方案可改善过敏性咳嗽患儿免疫功能,抑制患儿炎症,改善咳嗽控制效果,且不会增加不良反应。Objective:To investigate the effect of salbutamol and cetirizine combined therapy in patients with allergic cough.Methods:A total of 120 children with allergic cough in our hospital from December 2021 to February 2024 were selected,and they were divided into groups using a random number table method.The reference group consisted of 60 cases treated with cetirizine;60 cases in the experimental group were treated with cetirizine and salbutamol,and both groups were treated continuously for 2 weeks.Observe the levels of immunoglobulins,inflammatory factors,cough symptoms,and incidence of adverse reactions in two groups.The occurrence of two groups of immunoglobulin,inflammatory factors,cough symptoms and adverse reactions were Observed.Results:The levels of serum immunoglobulin IgG,IgA,and IgM in both groups after treatment were higher than before treatment,and the experimental group was higher than the reference group(P<0.05);Serum IL-6 and TNF after two groups of treatment-αThe level was lower than before treatment,but there was no significant difference between the two groups(P>0.05);Compared to before treatment,the cough symptom scores of both groups after treatment were lower,and the experimental group was lower than the reference group(P<0.05);There is not much difference in the total incidence of adverse reactions between the two groups of children.Conclusion:The combination regimen of salbutamol and cetirizine can improve the immune function,inhibit the inflammation and improve the cough control effect in children with allergic cough without increasing the adverse reactions.

关 键 词：沙丁胺醇 西替利嗪 过敏性咳嗽 免疫球蛋白 细胞因子水平 

分 类 号：R725.6[医药卫生—儿科]