海曲泊帕联合rhTPO治疗对免疫性血小板减少症患者血小板参数及出血的影响  

Effect of combination therapy of Hetrombopag and rhTPO on platelet parameters and bleeding in patients with immune thrombocytopenia

作　　者：颜静秀 董慧娟 郑林 沈佳坤 Yan Jing-xiu;Dong Hui-juan;Zheng Lin;Shen Jia-kun(Department of Hematology,Shangrao People's Hospital,Shangrao 334000,Jiangxi,China)

机构地区：[1]上饶市人民医院血液科,江西上饶334000

出　　处：《四川生理科学杂志》2024年第7期1537-1539,1588,共4页

摘　　要：目的:探究海曲泊帕联合重组人血小板生成素(Recombinant human thrombopoietin,rhTPO)治疗对免疫性血小板减少症(Immune thrombocytopenia,ITP)患者血小板参数及出血的影响。方法:选取2022年1月至2023年12月我院收治的62例ITP患者作为研究对象,采用随机抽黑白签的方法,分为观察组和对照组,各31例。对照组接受rhTPO治疗(300 U·kg^(-1),1次·d^(-1)),观察组在此基础上,增加海曲泊帕治疗(初始剂量为2.5 mg·d^(-1)),治疗21 d后,比较两组患者治疗效果;采用全自动血液分析仪检测平均血小板体积(Mean platelet volume,MPV),大血小板比率(Platelet large cell ratio,P-LCR),血小板比积(Plateletcrit,PCT)与血小板计数(Platelet count,PLT);治疗期间采用WHO出血程度分级标准评价出血率,并比较血小板输注率的差异。结果:观察组总有效率明显高于对照组(P<0.05);治疗后,两组血小板参数P-LCR水平均较治疗前明显降低,且观察组明显低于对照组(P<0.05);MPV、PCT和PLT水平均较治疗前明显升高,且观察组明显高于对照组(P<0.05);观察组1级出血率和需血小板输注率明显低于对照组(P<0.05),两组2级出血率无明显差异(P>0.05)。结论:海曲泊帕联合rhTPO治疗ITP疗效好,可改善血小板参数,降低出血和输注需求。Objective:To investigate the effects of combination therapy with recombinant human thrombopoietin(rhTPO)and Hetrombopag on platelet parameters and bleeding in patients with immune thrombocytopenia(ITP).Methods:Select 62 cases of ITP patients treated in our hospital from January 2022 to December 2023 as research subjects,and randomly divide them into the observation group and the control group,each with 31 cases,using the method of drawing black and white lots.The control group received rhTPO treatment(300 U·kg^(-1),once daily),while the observation group received additional Hetrombopag treatment(initial dose of 2.5 mg·d^(-1))on this basis.After 21 days of treatment,the therapeutic effects of the two groups were compared.An automatic blood analyzer was used to detect the following platelet parameters:Mean platelet volume(MPV);the ratio of large(mature)platelets to total platelet count:Platelet large cell ratio(P-LCR);the ratio of platelet volume to total blood volume:Plateletcrit(PCT);and Platelet count(PLT).During the treatment period,the bleeding rate was evaluated using the WHO bleeding grading criteria,and the difference in the rate of platelet transfusion was also compared between the two groups.Results:The overall effective rate in the observation group was significantly higher than that in the control group(P<0.05);after treatment,the platelet parameters P-LCR levels in both groups were significantly reduced compared to before treatment,and the observation group was significantly lower than the control group(P<0.05);the levels of MPV,PCT,and PLT were significantly increased compared to before treatment,and the observation group was significantly higher than the control group(P<0.05);the grade 1 bleeding rate and the rate of platelet transfusion required in the observation group were significantly lower than those in the control group(P<0.05),and there was no significant difference in the grade 2 bleeding rate between the two groups(P>0.05).Conclusion:The Hetrombopag and rhTPO treatment for ITP is effectiv

关 键 词：海曲泊帕 重组人血小板生成素 免疫性血小板减少症 血小板参数 

分 类 号：R558.2[医药卫生—血液循环系统疾病]