N-乙酰半胱氨酸联合硫酸特布他林雾化吸入治疗小儿喘息性肺炎的临床研究  

Clinical study of N-acetylcysteine combined with terbutaline sulfate in the treatment of asthmatic pneumonia in children

作　　者：张素艳 Zhang Su-yan(Department of Pediatrics,Xiayi Maternal and Child Health Hospital,Xiayi 476400,Henan,China)

机构地区：[1]夏邑县妇幼保健院儿科,河南夏邑476400

出　　处：《四川生理科学杂志》2024年第7期1562-1564,共3页

摘　　要：目的:探讨N-乙酰半胱氨酸联合硫酸特布他林雾化吸入治疗小儿喘息性肺炎的临床效果。方法:选择2020年1月至2023年9月期间在本院接受治疗的65例喘息性肺炎患儿作为研究对象,随机分为对照组(32例)和观察组(33例)。两组入院后均实施常规对症治疗,同时对照组采用硫酸特布他林雾化吸入治疗;观察组在对照组基础上联合N-乙酰半胱氨酸治疗。两组均连续治疗1 w。分析比较两组的临床症状消失时间,免疫功能[免疫球蛋白G(Immunoglobulin G,IgG)、免疫球蛋白A(Immunoglobulin A,IgA)、免疫球蛋白M(Immunoglobulin M,IgM)]以及不良反应发生率。结果:观察组的咳嗽、喘息以及湿啰音各项临床症状消失时间均比对照组显著缩短(P>0.05)。治疗后,两组的IgG、IgA、IgM水平均明显升高,且观察组的IgG、IgA、IgM水平均比对照组显著升高(P<0.05)。两组的不良反应发生率无显著差异。结论:采用N-乙酰半胱氨酸联合硫酸特布他林雾化吸入治疗,能缩短儿童喘息性肺炎症状缓解时间,改善患儿免疫力,且安全性较高。Objective:To investigate the clinical effect of N-acetylcysteine combined with terbutaline sulfate in the treatment of asthmatic pneumonia in children.Methods:A total of 65 children with asthmatic pneumonia who received treatment in our hospital from January 2020 to September 2023 were selected as study subjects and randomly divided into control group(32 cases)and observation group(33 cases).Both groups received routine symptomatic treatment after admission,while the control group received terbutaline sulfate aerosol inhalation treatment;Observation group was treated with n-acetylcysteine on the basis of control group.Both groups were treated continuously for 1 week.The disappearance time of clinical symptoms,immune function[Immunoglobulin G(IgG),Immunoglobulin A(IgA),Immunoglobulin M(IgM)]and the incidence of adverse reactions of the two groups were analyzed and compared.Results:The disappearance time of cough,wheezing and rales in observation group was significantly shorter than that in control group(P>0.05).After treatment,the levels of IgG,IgA and IgM in both groups were significantly increased,and the levels of IgG,IgA and IgM in the observation group were significantly higher than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups.Conclusion:N-acetylcysteine combined with terbutaline sulfate can shorten the time of symptom relief and improve the immunity of children with asthmatic pneumonia,with high safety.

关 键 词：喘息性肺炎 N-乙酰半胱氨酸 硫酸特布他林 免疫功能 安全性 

分 类 号：R725.6[医药卫生—儿科]