阿司匹林辅助治疗丙种球蛋白无反应性川崎病的效果研究  

Effect of aspirin in the adjuvant treatment of gammaglobulin non-reactive Kawasaki disease

作　　者：黄妮妮 Huang Ni-ni(Department of Pediatrics,Guangji Cardiovascular Hospital,Zhumadian 463000,Henan,China)

机构地区：[1]驻马店广济心血管病医院儿科,河南驻马店463000

出　　处：《四川生理科学杂志》2024年第7期1592-1594,共3页

摘　　要：目的:分析丙种球蛋白无反应性川崎病(Kawasaki disease,KD)经阿司匹林辅助治疗的效果。方法:选取2021年1月至2023年3月期间本院收治的77例丙种球蛋白无反应性KD患儿作为研究对象,采用随机数字表法将患儿分为对照组(n=38)和观察组(n=39)。对照组患儿接受常规挽救治疗;观察组在对照组基础上增加阿司匹林辅助治疗。分析比较两组的临床症状消退时间及住院时间、炎症因子水平、不良反应以及冠状动脉并发症的发生情况。结果:治疗后,观察组的发热、皮疹、黏膜充血、颈淋巴肿大消退时间及住院时间均明显短于对照组(P<0.05)。治疗后,两组C反应蛋白(C-reactive protein,CRP)、白细胞介素6(Interleukin-6,IL-6)、肿瘤坏死因子-ɑ(Tumor necrosis factor-ɑ,TNF-ɑ)均比治疗前明显降低,且观察组明显低于对照组(P<0.05)。两组治疗期间不良反应发生率无明显差异(P>0.05)。随访6 m间,观察组的冠状动脉扩张发生率明显低于对照组(P<0.05),两组的冠状动脉瘤发生率无明显差异(P>0.05)。结论:阿司匹林辅助可缩短丙种球蛋白无反应性KD患儿症状消退时间,减轻炎症反应,减少冠状动脉扩张发生,且安全性较高。Objective:To analyze the effect of aspirin adjuvant therapy on gammaglobulin non-reactive Kawasaki disease(KD).Methods:A total of 77 children with gammaglobulin non-reactive KD treated in our hospital from January 2021 to March 2023 were selected as the study objects.The children were divided into control group(n=38)and observation group(n=39)by random number table method.The control group received routine salvage treatment;Observation group was treated with aspirin on the basis of control group.The duration of clinical symptoms resolution,length of hospital stay,levels of inflammatory factors,adverse reactions and incidence of coronary complications were analyzed and compared between the two groups.Results:After treatment,the remission time of fever,rash,mucosal congestion,neck lymphoid enlargement and hospitalization time in observation group were significantly shorter than those in control group(P<0.05).After treatment,serum C-reactive protein,interleukin-6 and tumor necrosis factor-alpha in both groups were significantly reduced compared with before treatment,and observation group was significantly lower than control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).During 6-month follow-up,the incidence of coronary artery dilation was significantly lower in the observation group than in the control group(P<0.05),but there was no significant difference in the incidence of coronary aneurysm between the two groups(P>0.05).Conclusion:Aspirin adjuvant can shorten the time of symptom resolution,reduce inflammation,and reduce coronary artery dilation in children with gammaglobulin unresponsive KD,with high safety.

关 键 词：川崎病 丙种球蛋白无反应 阿司匹林 不良反应 冠状动脉扩张 

分 类 号：R725.4[医药卫生—儿科]