1137例男性HPV基因分型感染情况分析  

Analysis of infection status of human papillomavirus genotypes in 1137 males

作　　者：郑珊婉 李雯 杜洪 ZHENG Shanwan;LI Wen;DU Hong(Department of Pathology,the Second Affiliated Hospital of South China University of Technology(Guangzhou First People’s Hospital),Guangzhou 510180,China)

机构地区：[1]华南理工大学附属第二医院(广州市第一人民医院)病理科,广东广州510180

出　　处：《广州医药》2024年第6期633-637,共5页Guangzhou Medical Journal

摘　　要：目的探讨男性人乳头瘤病毒(HPV)基因分型感染情况。方法收集采用聚合酶链式反应反向斑点杂交法进行28种HPV基因分型检测的1137例男性检查结果,进行回顾性分析。结果1137例男性患者中阳性441例,阳性率为38.79%,感染率居前5位的亚型依次为HPV6(11.35%)、HPV11(7.92%)、HPV16(5.10%)、HPV52(3.52%)、HPV43(2.64%);就诊人群以20~39岁为主,感染人数也最多,各年龄组间阳性率比较差异无统计学意义(P>0.05),≥50岁组HPV52型阳性率高于20~29岁组(P<0.05)和30~39岁组(P<0.05)。单一感染占67.35%,多重感染占32.65%,单一感染中低危型占比最多(41.27%),多重感染中,二重感染占比最多(19.50%),高低危混合感染为各种类型感染之首(15.87%)。结论1137例样本中HPV阳性率为38.79%,感染亚型以HPV6、HPV11、HPV16、HPV52、HPV43为主,单一低危型感染较为常见,各年龄组间阳性率相近。Objective To investigate the genotypes of human papillomavirus(HPV)infection.Methods A total of 1137 male patients’diagnoses were collected and analyzed retrospectively,which came from the detections using polymerase chain reaction reverse dot blot hybridization to genotype 28 HPV.Results Among 1137 male patients,441 were HPV positive,with a positive rate of 38.79%,the infections of top five HPV types were HPV6(11.35%),HPV11(7.92%),HPV16(5.10%),HPV52(3.52%),HPV43(2.64%).The majority of the patients were the 20-39 age group,and the number of infections was also the highest.There was no statistical significance on the difference in the positive rate among different age groups(P>0.05).The positive rate of HPV52 in≥50 years old group was higher than the groups of aged 20~29(P<0.05)and 30~39(P<0.05).The single and multiple infections accounted for 67.35%and 32.65%.The low-risk HPV accounted for the highest proportion(41.27%)in single infections,while in patients with multiple infections,the proportion of dual infections was the largest(19.50%)and the high-and low-risk HPV mixed infections was the maximum of the infection types(15.87%).Conclusions The detection rate of positive HPV in 1137 male patients was 38.79%,mainly were type 6,type 11,type 16,type 52 and type 43,and the single low-risk HPV infected was common.Positive rates were similar among different age groups.

关 键 词：男性 人乳头瘤病毒 基因分型 感染 

分 类 号：R759[医药卫生—皮肤病学与性病学]