Exploring the relationship between Hashimoto's thyroiditis and male fertility:A meta-analytic and meta-regression perspective on hormonal and seminal factors  

作　　者：Seyed Sobhan Bahreiny Mojtaba Aghaei Mahdi Amraei Mohammad Reza Dabbagh 

机构地区：[1]Student Research Committee,Ahvaz Jundishapur University of Medical Sciences,Ahvaz,Iran [2]Medical Basic Sciences Research Institute,Physiology Research Center,Department of Physiology,School of Medicine,Ahvaz Jundishapur University of Medical Sciences,Ahvaz,Iran [3]Thalassemia&Hemoglobinopathy Research Center,Health Research Institute,Ahvaz Jundishapur University of Medical Sciences,Ahvaz,Iran [4]USERN Office,Ahvaz Jundishapur University of Medical Sciences,Ahvaz,Iran [5]Department of Biology,Faculty of Science,Shahid Chamran University of Ahvaz,Ahvaz,Iran

出　　处：《Asian pacific Journal of Reproduction》2024年第4期147-159,共13页亚太生殖杂志（英文版）

摘　　要：Objective:To explore the relationship between Hashimoto's autoimmune hypothyroidism(HT)and male fertility,focusing on hormonal and seminal factors.Methods:A systematic literature search was conducted across databases such as PubMed,Web of Science,EMBASE,Scopus,Cochrane,and Google Scholar,covering studies published from January 2000 to March 2024.Studies investigating the impact of HT on semen quality parameters and reproductive hormones were included.Pooled effect estimates were calculated using standard mean difference(SMD)and 95%confidence intervals(CI).Results:A total of 8 studies with 8965 participants were included.HT significantly affected semen quality and reproductive hormone levels.Specifically,there was a notable decrease in progressive morphology(SMD=-0.78;95%CI:-1.40 to-0.17;P=0.01)and sperm motility(SMD=-1.151;95%CI:-1.876 to-0.425;P=0.002).In addition,there were no significant changes in reproductive hormones,although there were elevated levels of luteinizing hormone(SMD=0.437;95%CI:0.000 to 0.874;P=0.050)and follicle-stimulating hormone(SMD=0.293;95%CI:-0.171 to 0.758;P=0.216),with a slight impact on testosterone levels(SMD=-1.143;95%CI:-2.487 to 0.200;P=0.095).Conclusions:This systematic review and meta-analysis provides robust evidence of the detrimental effects of HT on semen quality and reproductive hormones,underscoring the necessity for thorough evaluation and management of thyroid function in male infertility assessments.

关 键 词：Hashimoto thyroiditis Male fertility Semen quality Reproductive hormones META-ANALYSIS META-REGRESSION 

分 类 号：R581.4[医药卫生—内分泌]