The protective role of prebiotics and probiotics on diarrhea and gut damage in the rotavirus-infected piglets  

作　　者：Heng Yang Xiangqi Fan Xiangbing Mao Bing Yu Jun He Hui Yan Jianping Wang 

机构地区：[1]Institute of Animal Nutrition,Sichuan Agricultural University,Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education,Key Laboratory of Animal Disease-Resistant Nutrition and Feed of China Ministry of Agriculture and Rural Affairs,Key Laboratory of Animal Disease-Resistant Nutrition of Sichuan Province,No.211,Gongpinghuimin Road,Wenjiang District,Chengdu,Sichuan Province 611130,People’s Republic of China

出　　处：《Journal of Animal Science and Biotechnology》2024年第4期1424-1448,共25页畜牧与生物技术杂志（英文版）

基　　金：financially supported by 14^(th) Five-Year for Breeding Research Project of Sichuan Provincial Department of Science and Technology (2021YFYZ0008)。

摘　　要：Rotavirus is one of the pathogenic causes that induce diarrhea in young animals, especially piglets, worldwide. However, nowadays, there is no specific drug available to treat the disease, and the related vaccines have no obvious efficiency in some countries. Via analyzing the pathogenesis of rotavirus, it inducing diarrhea is mainly due to disturb enteric nervous system, destroy gut mucosal integrity, induce intracellular electrolyte imbalance, and impair gut microbiota and immunity. Many studies have already proved that prebiotics and probiotics can mitigate the damage and diarrhea induced by rotavirus infection in hosts. Based on these, the current review summarizes and discusses the effects and mechanisms of prebiotics and probiotics on rotavirus-induced diarrhea in piglets. This information will highlight the basis for the swine production utilization of prebiotics and probiotics in the prevention or treatment of rotavirus infection in the future.

关 键 词：DIARRHEA PIGLET PREBIOTICS PROBIOTICS ROTAVIRUS 

分 类 号：S858.28[农业科学—临床兽医学]