环氧化酶2在心肌缺血再灌注损伤中的研究进展  

Research progress in cyclooxygenase-2 in myocardial ischemia-reperfusion injury

作　　者：郑力榕 贾婷婷 张瑞芬 张海荣 ZHENG Lirong;JIA Tingting;ZHANG Ruifen;ZHANG Hairong(Department of Critical Care Medicine,School of Traditional Chinses Medicine Clinical Medicine,Inner Mongolia Medical University,Hohhot 010020;Department of Critical Care Medicine,Inner Mongolia Autonomous Region Hospital of Traditional Chinese Medicine,Hohhot 010020,China)

机构地区：[1]内蒙古医科大学中医临床医学院重症医学科,呼和浩特010020 [2]内蒙古自治区中医医院重症医学科,呼和浩特010020

出　　处：《临床与病理杂志》2024年第4期586-596,共11页Journal of Clinical and Pathological Research

基　　金：内蒙古自治区卫生健康委医疗卫生科技计划项目(20214152);内蒙古医科大学联合项目(YKD2022LH041)。

摘　　要：环氧化酶(cycloxygenase,COX)包括有2种异构酶:其中1种为COX-1,其对机体具有正常的生理保护性功能;另外1种为COX-2,主要参与机体的镇痛和抗炎作用。COX-2是心肌缺血再灌注损伤(myocardial ischemia-reperfusion injury,MI/RI)过程中炎症、动脉粥样硬化斑块、中毒性休克和细胞凋亡的重要介质,并导致多个组织出现功能障碍及损伤。非甾体的抗炎作用则主要与COX-2抑制剂有关,因此COX-2抑制剂可应用于MI/RI的临床治疗。Cyclooxygenase(COX)includes 2 isozymes:COX-1,which has a normal physiological protective function in the body,and COX-2,which mainly participates in analgesic and anti-inflammatory processes.COX-2 is an important mediator in myocardial ischemiareperfusion injury(MI/RI),contributing to inflammation,atherosclerotic plaque formation,toxic shock,and cell apoptosis,leading to dysfunction and damage in multiple tissues.Non-steroidal anti-inflammatory effects are primarily associated with COX-2 inhibitors,therefore which can be used in the clinical treatment of MI/RI.

关 键 词：环氧化酶-2 心肌缺血再灌注损伤 病理生理机制 治疗 

分 类 号：R54[医药卫生—心血管疾病]