海拔对高血压患者肠道菌群影响的研究进展  

Research progress on the effect of altitude on the gutmicrobiota in hypertensive patients

作　　者：普珍[1] 秦珊珊 白玛央吉[1] 罗布占堆[1] 旦增顿珠[1] Pu Zhen;Qin Shanshan;Baima Yangji;Luobu Zhandui;Danzeng Dunzhu(Medical College of Xizang University,Lhasa 850000,China)

机构地区：[1]西藏大学医学院,拉萨850000

出　　处：《西藏科技》2024年第6期35-41,共7页Xizang Science And Technology

基　　金：西藏自治区自然科学基金项目(XZ202201ZR0050G)。

摘　　要：高血压是心血管疾病的首要危险因素,据估计,全球每年有940万人因高血压及其并发症致死。高血压的发病机制复杂,越来越多的研究表明肠道菌群(Gutmicrobiota,Gm)与高血压的发病息息相关。为了探究高海拔对人类肠道菌群的影响以及在高血压中发挥的作用,文章从高原特殊环境入手,重点探讨肠道菌群与高血压的相互作用,高海拔环境下人体肠道菌群的变化以及肠道菌群在调节血压和预防高血压方面的治疗潜力。为高海拔地区高血压的防治研究提供了新的思路。Hypertension is the leading risk factor for cardiovascular disease,with an estimated 9.4 million deaths each year from hypertension and its complications worldwide.The pathogenesis of hypertension is complex,and there is increasing evidence to support the role of gut microbiota(GM)in hypertension,with the environment being an important factor affecting gut microbiota.In order to explore the role of the effects of high altitude on human gut microbiota in hypertension,this paper focuses on the interaction between gut microbiota and hypertension,the chang-es of human gut microbiota in high-altitude environment,and the therapeutic potential of gut microbiota in regulating blood pressure and preventing hypertension from the special environment of the plateau.It provides a new idea for the prevention and treatment of hypertension in high-altitude areas.

关 键 词：肠道菌群 高血压 高海拔 低氧 

分 类 号：R544.1[医药卫生—心血管疾病]