心钠素及其受体-A在早发型子痫前期中的表达及相关性研究  

Expression and Correlation of Atrial Natriuretic Factor and its Receptor-a in Early Onset Preeclampsia

作　　者：王刚[1] 宋立猛 WANG Gang;SONG Limeng(Graduate School of Baotou Medical College,Inner Mongolia University of Science and Technology,Baotou 014040 China;Department of Obstetrics,People's Hospital of Inner Mongolia Autonomous Region,Hohhot 010017 China)

机构地区：[1]内蒙古科技大学包头医学院研究生学院,内蒙古包头014040 [2]内蒙古自治区人民医院产科,呼和浩特010017

出　　处：《内蒙古医学杂志》2024年第6期641-644,F0002,共5页Inner Mongolia Medical Journal

基　　金：内蒙古自治区卫健委科研项目(编号:202201057)。

摘　　要：目的观察心钠素(ANP)及其受体-A(NPR-A)在早发型子痫前期孕妇胎盘中的表达及相关性研究。方法随机选取正常妊娠的足月孕妇15例,患有早发型子痫前期因病情原因选择剖宫产手术终止妊娠的孕妇15例,分别收集胎盘组织。通过免疫组化和免疫印迹技术检测ANP及NPR-A在正常妊娠孕妇和患有早发型子痫前期孕妇胎盘中的表达及分布。结果ANP及NPR-A在正常妊娠孕妇和患有早发型子痫前期孕妇胎盘组织中均有表达。在早发型子痫前期孕妇的胎盘组织中ANP的表达量与正常妊娠孕妇胎盘组织中ANP的表达量差异无统计学意义(P>0.05);早发型子痫前期孕妇的胎盘组织中NPR-A的表达量与正常妊娠孕妇胎盘组织中NPR-A的表达量相比差异有统计学意义(P<0.05)。结论合体滋养细胞通过ANP及NPR-A来调节母胎循环;ANP及NPR-A的功能障碍可能参与了子痫前期的发病,影响绒毛滋养细胞的侵入和子宫螺旋小动脉的重铸,从而导致子痫前期的发生。Objective To investigate the expression and correlation of atrial natriuretic peptide(ANP)and its receptor-a(NPR-A)in placenta of pregnant women with early-onset preeclampsia.Methods A total of 15 full-term pregnant women with normal pregnancy and 15 patients with early-onset preeclampsia were randomly selected to terminate pregnancy by cesarean section.Placenta tissue was collected.The expression and distribution of ANP and NPR-A in the placenta of normal pregnant women and women with early-onset preeclampsia were detected by immunohistochemistry and western blot.Results ANP and NPR-A are expressed in placental tissues of normal pregnant women and women with early-onset preeclampsia.There was no significant difference in the expression of ANP between the placental tissues of pregnant women with early-onset preeclampsia and that of normal pregnant women(P>0.05).The expression level of NPR-A in placental tissues of pregnant women with early-onset preeclampsia was significantly different from that of normal pregnant women(P<0.05).Conclusion Syncytiotrophoblast regulates maternal-fetal circulation through ANP and NPR-A.The dysfunction of ANP and NPR-A may be involved in the onset of preeclampsia.ANP and NPR-A affect the invasion of villous trophoblast cells and the recast of uterine spiral arteriolae,thus leading to the occurrence of preeclampsia.

关 键 词：早发型子痫前期 心钠素 心钠素受体-A 

分 类 号：R714.2[医药卫生—妇产科学]