盐酸非索非那定片递减疗法治疗慢性自发性荨麻疹的临床疗效分析  

Clinical efficacy analysis of fexofenadine hydrochloride tablets decreasing therapy in the treatment of chronic spontaneous urticaria

作　　者：刘海兵 LIU Hai-bing(Department of Dermatology,Jianli Traditional Chinese Medicine Hospital,Jingzhou 433300,China)

机构地区：[1]监利市中医医院皮肤科,湖北荆州433300

出　　处：《中国处方药》2024年第7期70-73,共4页Journal of China Prescription Drug

摘　　要：目的评价盐酸非索非那定片递减疗法治疗慢性自发性荨麻疹的临床疗效。方法将2022年3月~2023年9月收治的110例慢性自发性荨麻疹患者按照随机数表法随机分为对照组(n=55)和观察组(n=55),均使用盐酸非索非那定片进行治疗:对照组每天服用相同剂量药物(120 mg),观察组患者接受剂量递减治疗,治疗1个月后逐渐递减药物剂量,用药2个月后控制在最小用药量内。对比两组患者的用药效果。结果荨麻疹活动度评分以及皮肤病生活质量评分结果显示,两组患者治疗1、2、3个月后的疾病状态、生活质量与治疗前比较,差异有统计学意义(P<0.05);两组患者每个月的疾病改善程度以及生活质量比较,差异无统计学意义(P>0.05);抗组胺药物用药剂量结果显示,观察组患者治疗第2个月和第3个月,用药剂量显著低于对照组(P<0.05),且每个月的用药剂量与前1个月比较均明显降低(P<0.05)。两组用药不良反应发生情况比较,差异无统计学意义(P>0.05)。结论慢性自发性荨麻疹使用盐酸非索非那定片递减疗法进行治疗的临床疗效与常规剂量治疗效果相近,具有良好的治疗效果和安全性。Objective To evaluate the clinical efficacy of fexofenadine hydrochloride tablets decreasing therapy in the treatment of chronic spontaneous urticaria.Methods 110 patients with chronic spontaneous urticaria admitted from March 2022 to September 2023 were randomly divided into the control group(n=55)and the observation group(n=55)according to the random number table method.Both groups were treated with fexofenadine hydrochloride tablets.The control group received the same dose of medication(120 mg)every day,while the observation group received dose decreasing treatment.After one month of treatment,the drug dose gradually decreased,and after two months of medication,it was controlled within the minimum dosage.Compare the medication effects of two groups of patients.Results The results of Urticaria activity score and dermatology quality of life score showed a statistically significant difference between disease status,quality of life after 1,2 and 3 months of treatment and before treatment(P<0.05).There was no statistically significant difference in the degree of disease improvement and quality of life between the two groups of patients each month(P>0.05);The results of antihistamine medication dosage showed that the observation group patients had significantly lower medication dosage than the control group in the second and third months of treatment(P<0.05),and the medication dosage per month was significantly lower than the previous month(P<0.05).The occurrence of adverse drug reactions between the two groups was similar and showed no significant difference(P>0.05).Conclusion The clinical efficacy of fexofenadine hydrochloride tablets decreasing therapy for chronic spontaneous urticaria is similar to that of conventional dose therapy,with good therapeutic effect and safety.

关 键 词：盐酸非索非那定片 药物递减 慢性自发性荨麻疹 

分 类 号：R758.24[医药卫生—皮肤病学与性病学] R969[医药卫生—临床医学]