辅酶A辅助无创正压通气治疗慢性阻塞性肺疾病急性加重的效果观察  

Observation on the effect of non-invasive positive pressure ventilation assisted by coenzyme A in the treatment of acute exacerbation of chronic obstructive pulmonary diseases

作　　者：王萌萌 王辰 欧阳文浩 胡斌[1] WANG Meng-meng;WANG Chen;OUYANG Wen-hao(Department of Respiratory and Critical Care Medicine,Shanghai Xuhui Central Hospital,Shanghai 200031,China)

机构地区：[1]上海市徐汇区中心医院呼吸与危重症医学科,上海200031

出　　处：《中国处方药》2024年第7期85-87,共3页Journal of China Prescription Drug

基　　金：2023年徐汇区医学重点学科建设高峰学科资助项目(SHXHZDXK202312)。

摘　　要：目的分析辅酶A辅助无创正压通气治疗慢性阻塞性肺疾病(慢阻肺)急性加重的效果。方法选取某院2021~2023年的92例慢阻肺急性加重患者,随机分成两组。对照组(46例)采用无创正压通气进行治疗,研究组(46例)采用辅酶A辅助无创正压通气进行治疗。比较两组患者血气指标、血清指标、免疫功能。结果治疗前后,两组PaO_(2)、PaCO_(2)差异无统计学意义(P>0.05);治疗后,研究组pH高于对照组(P<0.05);治疗后,研究组铁、锌水平低于对照组,CD4^(+)、CD4^(+)/CD8^(+)水平高于对照组,CD8^(+)低于对照组(P<0.05)。结论辅酶A辅助无创正压通气治疗慢阻肺急性加重效果更好,可改善患者免疫功能,纠正患者铁、锌含量。Objective To analyze the effect of non-invasive positive pressure ventilation assisted by coenzyme A on acute exacerbation of chronic obstructive pulmonary disease(COPD).Methods 92 patients with acute COPD exacerbation from 2021 to 2023 were randomly divided into two groups.The control group(n=46)was treated with non-invasive positive pressure ventilation,and the study group(n=46)was treated with non-invasive positive pressure ventilation assisted by coenzyme A.Blood gas index,serum index and immune function were compared between the two groups.Results There was no significant difference in PaO_(2)and PaCO_(2)between the two groups before and after treatment(P>0.05).After treatment,the pH of the study group was higher than that of the control group(P<0.05).After treatment,iron and zinc levels in the study group were lower than those in the control group,CD4^(+),CD4^(+)/CD8^(+)levels were higher than those in the control group,and CD8^(+)levels were lower than those in the control group(P<0.05).Conclusion Coenzyme A assisted non-invasive positive pressure ventilation is more effective in the treatment of acute COPD exacerbation,which can improve the immune function and correct the content of iron and zinc in patients.

关 键 词：辅酶A 无创正压通气 慢性阻塞性肺疾病急性加重 效果观察 

分 类 号：R563.9[医药卫生—呼吸系统]