两种不同多个混合纯音频率声治疗慢性主观性耳鸣的疗效分析  

Analysis of the therapeutic effect of two different multiple mixed pure tone frequency sounds on the treatment of chronic subjective tinnitus

作　　者：何杨新 关山越[1] 李卫红[1] HE Yang-xin;GUAN Shan-yue;LI Wei-hong(Department of Otolaryngology,the Second People's Hospital of Zhaoqing City,Zhaoqing 526060,China)

机构地区：[1]肇庆市第二人民医院耳鼻喉科,广东肇庆526060

出　　处：《中国处方药》2024年第7期183-185,共3页Journal of China Prescription Drug

摘　　要：目的探讨两种不同多个混合纯音频率声在慢性主观性耳鸣患者中的治疗效果。方法选择2021年4月~2023年4月慢性主观性耳鸣患者100例为对象,用随机数字表法分为两组各50例。两组均采用常规方法治疗,在此基础上,对照组声治疗以耳鸣检测中测得的耳鸣频率为中心频率,由7倍频程的不同频率纯音构成,观察组以耳鸣检测中测得的耳鸣频率为中心频率,由9个1/3频程的不同频率纯音构成,两组均完成3个月治疗,比较两组有效率、耳鸣残障量表(THI)、耳鸣严重程度评估量表(TEQ)、血清细胞黏附因子-1(sVCAM-1)及一氧化氮(NO)水平。结果治疗3个月后,观察组有效率为96.00%,高于对照组84.00%(P<0.05);治疗3个月后,观察组功能性、情感性、灾难性及TEQ评分,sVCAM-1及NO水平低于对照组(P<0.05)。结论由9个1/3频程的不同频率纯音构成的混合音频率声治疗慢性主观性耳鸣有效率较高,能改善患者耳鸣症状,有助于降低sVCAM-1及NO水平。Objective To explore the therapeutic effects of two different multiple mixed pure tone frequency sounds in patients with chronic subjective tinnitus.Methods A total of 100 patients with chronic subjective tinnitus from April 2021 to April 2023 were selected as the study subjects,and divided into two groups for 50 patients in each group by random number table.Both groups were treated with conventional methods,and,based on this,the control group acoustic treatment received the tinnitus frequency measured in the tinnitus detection as the center frequency,consisting of pure tones of different frequencies in 7 times frequency range.The observation group received the tinnitus frequency measured in the tinnitus detection as the center frequency,consisting of 9 pure tones of different frequencies in 1/3 frequency range.Both groups completed 3 months of treatment.The effectiveness,tinnitus handicap inventory(THI),and tinnitus evaluation questionnaire(TEQ),serum cell adhesion factor 1(sVCAM-1)and nitric oxide(NO)levels were compared between the two groups.Results The effective rate of the observation group after 3 months of treatment was 96.00%,which was higher than that of the control group(84.00%,P<0.05);after 3 months of intervention,the functional,emotional,catastrophic,TEQ scores and sVCAM-1,NO levels of the observation group were lower than those of the control group(P<0.05).Conclusion The mixed frequency sound consisting of 91/3 frequency range pure tones with different frequencies has a higher effective rate in the treatment of chronic subjective tinnitus.It can improve patients'tinnitus symptoms,and help reduce sVCAM-1 and NO levels.

关 键 词：混合纯音频率声 耳鸣残障量表 耳鸣严重程度 血清细胞黏附因子-1 一氧化氮 

分 类 号：R764.45[医药卫生—耳鼻咽喉科]