水凝胶材料在肾组织工程中的应用研究  

Application of hydrogel materials in renal tissue engineering

作　　者：王海洋[1] 陆子介 方超 李翔[1,2,3,4] WANG Haiyang;LU Zje;FANG Chao;LI Xiang(ZJU-Xinchang Joint Innovation Center(TianMu Laboratory),Shaoxing,Zhejiang 312532,P.R.China;Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University,Hangzhou,Zhejiang 310018,P.R.China;iBioMat PharmTek Co.Ltd,Hangzhou,Zhejiang 311100,P.R.China;School of Materials Science and Engineering,Zhejiang University,Hangzhou,Zhejiang 310027,P.R.China)

机构地区：[1]浙江大学-新昌联合创新中心(天姥实验室),浙江绍兴312532 [2]浙江大学智能创新药物研究院,杭州310018 [3]智元柏迈(杭州)科技有限公司,杭州311100 [4]浙江大学材料科学与工程学院,杭州310027

出　　处：《华西医学》2024年第7期1010-1014,共5页West China Medical Journal

摘　　要：急性肾损伤是全球关注的公共卫生问题,其治疗和管理策略不断进步。除了传统的肾脏替代疗法外,近年来的研究还集中在全器官工程以及用于体内再生的肾脏辅助设备和制剂的生物制造上。水凝胶材料因其良好的生物相容性、热稳定性和可调控的生化及力学性能,在肾组织工程中显示出巨大的潜力。该文综述了各类水凝胶材料在肾组织工程中用于促进肾脏再生方面的研究,讨论了天然水凝胶和合成水凝胶各自的特点与用途,旨在进一步推动其在临床中的应用。Acute kidney injury is a worldwide public health issue,and its treatment and management strategies continue to advance.In addition to traditional kidney replacement therapy,research in recent years has been focused on whole organ engineering and biofabrication of kidney assistive devices and bioinjections for in-body regeneration.Hydrogel materials show great potential in renal tissue engineering because of their good biocompatibility,thermal stability and controllable biochemical and mechanical properties.This article reviews the application of various hydrogel materials in renal tissue engineering to promote kidney regeneration and discusses the characteristics and applications of natural hydrogels and synthetic hydrogels,which is expected to further promote their clinical applications.

关 键 词：急性肾损伤 肾组织工程 水凝胶 肾脏替代疗法 

分 类 号：R318.08[医药卫生—生物医学工程] R692.5[医药卫生—基础医学]