我国中老年血清尿酸/高密度脂蛋白胆固醇比值与慢性肾脏病的相关性研究  

Correlation between Serum Uric acid to high-density lipoprotein cholesterol ratio and chronic kidney disease in middle-aged and elderly population in China

作　　者：卢周裕 吴瑞鹏 章梦君 李文源[1,2] LU Zhou-yu;WU Rui-peng;ZHANG Meng-jun;LI Wen-yuan(School of Public Health,Southern Medical University,Guangzhou,Guangdong 510515,China;不详)

机构地区：[1]南方医科大学公共卫生学院,广东广州510515 [2]南方医科大学南方医院,广东广州510515 [3]南方医科大学卫生管理学院,广东广州510515

出　　处：《现代预防医学》2024年第14期2507-2512,2547,共7页Modern Preventive Medicine

基　　金：国家科技重大专项(2020ZX09201-017);广东省重点领域研发计划项目(2019B020227004)。

摘　　要：目的探究我国中老年血清尿酸/高密度脂蛋白胆固醇比值(UHR)与慢性肾脏病(CKD)之间的关系。方法采用中国健康与养老追踪调查(CHARLS)数据,选取9204名45岁及以上受访者为研究对象。多因素logistics回归分析用于评估UHR与CKD关系。利用受试者工作特征(ROC)曲线评估UHR对CKD的预测价值。结果研究对象平均年龄60.78±9.32岁,CKD患病率为3.97%。与UHR最低四分位组(Q1组)相比,最高四分位组(Q4组)患CKD风险增加(OR=12.01,95%CI:7.50~20.00)。ROC曲线分析中,中老年UHR预测CKD的ROC曲线下面积(AUC)为0.76(95%CI:0.73~0.78),男性UHR预测CKD的AUC为0.74(95%CI:0.70~0.77),女性UHR预测CKD的AUC为0.77(95%CI:0.73~0.81)。结论我国中老年UHR与CKD存在独立相关关系,UHR可能是中老年CKD的危险因素且对CKD预测具有良好价值。Objective To investigate the correlation between UHR and CKD in middle-aged and elderly population.Methods The data of this study was obtained from 2015 China Health and Retirement Longitudinal Survey(CHARLS).A total of 9204 people≥45 years old were included.Multivariate Logistics regression analysis was used to analyze the correlation between UHR and CKD.The receiver operating characteristic(ROC)curves was used to analyze the predictive value of UHR for the risk of CKD.Results The subjects who we included have the mean age of 60.78±9.32 years with the prevalence of CKD of 3.97%.The odd rations for the highest quartile group(Q4group)of UHR was increased for CKD(OR=12.01,95%CI:7.50-20.00).ROC curve analysis showed that the area under the ROC Curve(AUC)for UHR predicting CKD for middle-aged and elderly population was 0.76(95%CI:0.73-0.78),the AUC for UHR predicting CKD for male group was 0.74(95%CI:0.70-0.77)and the AUC for UHR predicting CKD for female group was 0.77(95%CI:0.73-0.81).Conclusion There was a positive correlation between the increased UHR level and risk of CKD among the middle-aged and elderly population in China.UHR might serve as a risk factor and demonstrated good predictive value for CKD in the middle-aged and elderly population in China.

关 键 词：慢性肾脏病 血清尿酸 血清高密度脂蛋白胆固醇 中国健康与养老追踪调查 预测 LOGISTIC回归 

分 类 号：R692[医药卫生—泌尿科学]