淫羊藿苷促进关节软骨损伤修复作用机制研究进展  

Research progress on active mechanism of icarin in promoting repair of articular cartilage damage

作　　者：刘琪 李林臻 张君涛[1,2] LIU Qi;LI Linzhen;ZHANG Juntao(The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300381,China;National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion,Tianjin 300381,China)

机构地区：[1]天津中医药大学第一附属医院,天津300381 [2]国家中医针灸临床医学研究中心,天津300381

出　　处：《药物评价研究》2024年第6期1393-1399,共7页Drug Evaluation Research

基　　金：国家自然科学基金面上项目(82074470,51573137)。

摘　　要：淫羊藿苷是补肾类中药淫羊藿的主要活性成分,属异戊烯基黄酮醇类化合物,具有免疫调节、抗炎、抗氧化应激、抗肿瘤、抗衰老和抗骨质疏松等多种药理活性,对神经、免疫、肿瘤、内分泌、心脑血管和肌肉骨骼系统等疾病均具有良好的功效,尤其对骨骼系统疾病具有多通道、多靶点的活性作用,在关节软骨损伤性疾病中具有潜在应用优势。淫羊藿苷可通过促进软骨细胞增殖分化及抑制过度凋亡、减少炎症因子释放、抑制软骨下骨结构重塑、促进关节软骨细胞外基质合成、促进骨髓间充质干细胞迁移和成软骨分化等多种作用机制来促进关节软骨损伤修复。对淫羊藿苷在治疗关节软骨损伤疾病中发挥不同修复作用及其机制进行综述,以期为深入研究和相关药物研发提供参考依据。Icarin is the main active monomer of the kidney tonic Chinese medicine Epimedi Folium,belonging to isopentenylflavonol compounds,with multiple pharmacological activities such as immunomodulation,anti-inflammation,antioxidative stress,anti-tumor and aging,anti-osteoporosis and other multiple pharmacological activities,which is effective in neurological,immunological,oncological,endocrinological,cardio-cerebral,cerebral,vascular and musculoskeletal system disorders,especially in the skeletal system diseases,with a multichannel and multi-targeted active effect,in particular,it has multichannel and multi-target active effects on skeletal system diseases,and has potential application advantages in articular cartilage damage diseases.Icarin can promote the repair of articular cartilage damage by promoting chondrocyte proliferation and differentiation,inhibiting excessive apoptosis,decreasing the release of inflammatory factors,inhibiting the remodeling of subchondral bone structure,promoting the synthesis of extracellular matrix in articular cartilage,and promoting the migration and chondrogenic differentiation of bone marrow mesenchymal stem cells,and many other mechanisms of action.Now,we review the different repairing effects played by icarin in the treatment of articular cartilage damage diseases and its mechanism,in order to provide reference basis for in-depth research and related drug development.

关 键 词：关节软骨损伤 淫羊藿苷 软骨修复 作用机制 成软骨分化 

分 类 号：R286.7[医药卫生—中药学]