门诊输注盐酸左氧氟沙星注射剂不良反应的相关因素及预见性护理效果研究  

Study on the Related Factors and Predictive Nursing Effects of Adverse Drug Reactions of Levofloxacin Hydrochloride Injection in Outpatient Patients

作　　者：刘玲玲 陈芝薇[1] 高碧华 LIU Ling-ling;CHEN Zhi-wei;GAO Bi-hua(Fujian Provincial Hospital,Fuzhou 350001,China)

机构地区：[1]福建省立医院,福建福州350001

出　　处：《海峡药学》2024年第7期95-98,共4页Strait Pharmaceutical Journal

摘　　要：目的 分析总结门诊输注左氧氟沙星注射剂治疗中患者出现不良反应的特点、相关影响因素,试探讨相关预见性护理措施并评价护理效果。方法 选取我院门诊2022年6月~2023年6月一年间输注左氧氟沙星注射剂246例。采用随机数表法将246例患者分为对照组和干预组,每组123例,对照组给予常规护理,干预组给予预见性护理,比较两组患者不良反应(Adverse drug Reaction, ADR)发生率,经分组护理后,246例患者中其中出现ADR 68例。分析ADR病例的年龄、性别、基础疾病类型、不良反应发生时间、既往用药过敏史、产生ADR时用药次数等特点,总结影响ADR的相关因素。结果 干预组患者的ADR发生率显著低于对照组(P<0.05);68例ADR中,年龄偏大、具有用药过敏史、不良反应发生时间更早、首次用药即产生ADR、受累器官为中枢神经系统的患者的比率显著更高(P<0.05)。结论 年龄偏大、具有用药过敏史、不良反应发生时间更早、首次用药出现ADR的患者在输注左氧氟沙星后更容易出现ADR,针对上述影响因素制定相关预见性护理措施,可有效减少ADR事件,有临床应用价值。OBJECTIVE To analyze and summarize the characteristics and related influencing factors of adverse reactions in patients undergoing outpatient infusion of levofloxacin injection,explore relevant predictive nursing measures,and evaluate nursing effectiveness.METHODS 246 patients who received levofloxacin injections in our outpatient department from June 2022 to June 2023 were selected and divided into two groups,control group and intervention group,by using the average grouping method with 123 patients in each group.The control group received routine care,while the intervention group received predictive care.The incidences of ADR(Adverse Drug Reaction)were compared between the two groups.After group nursing care,68 of the 246 patients experienced ADR.The characteristics of the ADR cases were analyzed,including age,gender,disease type,time of ADR occurrence,past medication allergy history,and frequency of ADR.The factors related to ADR were summarized.RESULTS The incidence of ADR in the intervention group was significantly lower than that in the control group(P<0.05).The proportion of patients who are older and have a history of medication allergies,earlier onset of ADR,ADR occurring on the first medication,and affected organs in the central nervous system is significantly higher(P<0.05).CONCLUSION Patients who are older,have a history of medication allergies,have earlier onset of adverse reactions,and are more prone to ADR after levofloxacin infusion.Developing predictive nursing measures for these influencing factors can effectively reduce the ADR events and is worthy of clinical application.

关 键 词：盐酸左氧氟沙星注射剂 不良反应 相关性因素 预见性护理 

分 类 号：R969.3[医药卫生—药理学]