奥卡西平致血液系统损害及肝损伤1例  

One Case of Hematologic Damage and Liver Injury Induced by Oxcarbazepine

作　　者：杨暄 YANG Xuan(Department of Pharmacy,Huai′an Third People′s Hospital,Huai′an 223001,China)

机构地区：[1]淮安市第三人民医院药学部,江苏淮安223001

出　　处：《海峡药学》2024年第7期101-103,共3页Strait Pharmaceutical Journal

摘　　要：1例28岁男性患者因癫痫发作予奥卡西平1日750 mg,连续用药6天后加量至1日900 mg。3天后复查结果示,患者白细胞、中性粒细胞以及血小板减少,且肝功能严重异常。考虑为奥卡西平引起的血液系统损害及肝损伤,停奥卡西平并换托吡酯抗癫痫。患者出院前复查肝功能指标较前明显好转,血常规指标恢复正常。A-28-year-old male was given oxcarbazepine 750 mg·d-1 because of epileptic seizure,after 6 days of continuous administration,the dose was increased to 900 mg·d-1.Re-examination results after 3 days showed that,the patient′s Leukocyte,Neutrophils and Platelet were reduced,and liver function is severely abnormal.Considering the blood system damage and liver damage caused by oxcarbazepine,stop oxcarbazepine and change topiramate for antiepileptic.The liver function has significantly improved compared to before,and blood routine has returned to normal.

关 键 词：奥卡西平 血液系统损害 肝损伤 

分 类 号：R969.3[医药卫生—药理学]