持续气道正压通气对阻塞性睡眠呼吸暂停低通气综合征相关性高血压患者血压及相关炎症因子的影响  

Effect of continuous positive airway pressure on blood pressure and related inflammatory factors in patients with obstructive sleep apnea hypopnea syndrome related

作　　者：张慧英[1] 王树坤 端木鲁健 ZHANG Huiying;WANG Shukun;DUANMU Lujian(Internal Medicine Teaching and Research Section,Department of Clinical Medicine,Heze Medical College,Shandong Province,Heze 274000,China;Department of General Surgery,Affiliated Hospital of Heze Medical College,Shandong Province,Heze 274000,China)

机构地区：[1]菏泽医学专科学校临床医学系内科学教研室,山东菏泽274000 [2]菏泽医学专科学校附属医院普外科,山东菏泽274000

出　　处：《中国当代医药》2024年第21期33-37,共5页China Modern Medicine

摘　　要：目的探讨持续气道正压通气(CPAP)对阻塞性睡眠呼吸暂停低通气综合征(OSAHS)相关性高血压患者血压及相关炎症因子的影响。方法选取2020年1月至2022年5月菏泽医学专科学校附属医院收治的100例OSAHS相关性高血压患者作为研究对象,按照随机数字表法分为CPAP组(50例)和对照组(50例)。对照组给予常规降压药物治疗,CPAP组在对照组治疗方法的基础上给予CPAP,比较两组治疗前后的动态血压、睡眠监测指标及相关炎症因子水平。结果治疗后,CPAP组的24h平均收缩压(24hSBP)24h平均舒张压(24hDBP)、夜间平均收缩压(nSBP)夜间平均舒张压(nDBP)、白天平均收缩压(dSBP)、白天平均舒张压(dDBP)均低于对照组,差异有统计学意义(P<0.05)。治疗后,CPAP组的呼吸暂停低通气指数(AHI)氧减指数(ODI)均低于对照组,最低血氧饱和度(LSaO_(2))平均血氧饱和度(MSaO_(2))均高于对照组,差异有统计学意义(P<0.05)。治疗后,CPAP组的高敏C反应蛋白(hs-CRP)白细胞介素-6(IL-6)肿瘤坏死因子-α(TNF-α)均低于对照组,差异有统计学意义(P<0.05)。结论CPAP能显著降低OSAHS相关性高血压患者的血压水平和相关炎症因子水平,并改善其呼吸功能。Objective To investigate the effect of continuous positive airway pressure(CPAP)on blood pressure and related inflammatory factors in patients with obstructive sleep apnea hypopnea syndrome(OSAHS)related hypertension.Methods A total of 100 patients with OSAHS related hypertension admitted to Affiliated Hospital of Heze Medical College from Jan-uary 2020 to May 2022 were selected as the research objects.According to the random number table method,they were di-vided into CPAP group(50 cases)and control group(50 cases).The control group was given conventional antihypertensive drug treatment,and the CPAP group was given CPAP on the basis of the treatment method of the control group.The levels of ambulatory blood pressure,sleep monitoring indexes and related inflammatory factors before and after treatment were com-pared between the two groups.Results After treatment,the 24-hour average systolic blood pressure(24 hSBP),24-hour av-erage diastolic blood pressure(24 hDBP),night average systolic blood pressure(nSBP),night average diastolic blood pres-sure(nDBP),daytime average systolic blood pressure(dSBP),and daytime average diastolic blood pressure(dDBP)in the CPAP group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the apnea hypopnea index(AHI)and oxygen desaturation index(ODI)of the CPAP group were lower than those of the control group,and the lowest blood oxygen saturation(LSaO_(2))and mean oxygen saturation(MSaO_(2))were higher than those of the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of high-sensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)in the CPAP group were lower than those in the control group,and the dfferences were statisticlly significant(P<0.05).Conclusion CPAP can significantly reduce the blood pressure and related inflammatory factors in patients with OSAHS related hyper-tension,and improve their respiratory function.

关 键 词：持续气道正压通气 阻塞性睡眠呼吸暂停低通气综合征 高血压 炎症因子 

分 类 号：R544.1[医药卫生—心血管疾病] R767.13[医药卫生—内科学]