调补肺肾治疗慢性阻塞性肺疾病缓解期临床研究  

Clinical study on the remission stage of chronic obstructive pulmonary disease treated by regulate and reinforce lung and kidney

作　　者：王大江[1] 龙琼萍 WANG Dajiang;LONG Qiongping(Department of Lung Disease,Jiangxi Chest Hospital,Jiangxi Province,Nanchang 330000,China)

机构地区：[1]江西省胸科医院中西医结合肺病科,江西南昌330000

出　　处：《中国当代医药》2024年第21期119-122,127,共5页China Modern Medicine

基　　金：江西省中医药管理局科研项目(2020A0230)。

摘　　要：目的探讨调补肺肾治疗慢性阻塞性肺疾病(COPD)缓解期的临床效果。方法选取2021年5月至2023年5月江西省胸科医院收治的94例COPD缓解期患者作为研究对象,按照随机数字表法分为对照组(47例)和观察组(47例)。对照组患者采用常规西医治疗,观察组患者加用调补肺肾治疗(六味地黄汤加减和揿针特定穴位治疗),两组均连续治疗12周。比较两组患者的临床疗效、肺功能、血气指标、呼吸困难程度、生活质量、中医证候积分及不良反应。结果观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05);两组治疗前第1秒用力呼气容积(FEV_(1))、用力肺活量(FVC)、FEV_(1)/FVC、动脉二氧化碳分压(PaCO_(2))、动脉氧分压(PaO_(2))、中医证候积分、改良版英国医学研究委员会呼吸问卷(mMRC)、COPD评估测试问卷(CAT)评分比较,差异无统计学意义(P>0.05);两组治疗后FEV_(1)、FVC、FEV_(1)/FVC、PaO_(2)高于本组治疗前,PaCO_(2)、中医证候积分及mMRC、CAT评分低于本组治疗前,差异有统计学意义(P<0.05);观察组治疗后FEV_(1)、FVC、FEV_(1)/FVC、PaO_(2)高于对照组,PaCO_(2)、中医证候积分及mMRC、CAT评分低于对照组,差异有统计学意义(P<0.05);两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论缓解期COPD患者应用调补肺肾治疗具有较高的价值,可改善通气及肺功能,缓解呼吸困难,提高生活质量,安全可靠,效果显著。Objective To explore the clinical effect of the remission stage of chronic obstructive pulmonary disease(COPD)treated by regulate and reinforce lung and kidney.Methods A total of 94 patients with COPD in remission stage admitted to Jiangxi Chest Hospital from May 2021 to May 2023 were selected as the research objects.According to the random number table method,they were divided into the control group(47 cases)and the observation group(47 cases).The control group was treated with conventional western medicine,and the observation group was treated with regulate and reinforce lung and kid-ney(Liuwei Dihuang Decoction modified and subtract and pressing specific acupuncture points treatment).Both groups were treated continuously for12 weeks.The clinical efficacy,lung function,blood gas index,dyspnea degree,quality oflife,tradi tional Chinese medicine syndrome score and adverse reactions were compared between the two groups.Results The total ef-fective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).There were no statistically significant differences in forced expiratory volume in first second(FEV_(1)),forced vital capacity(FVC),FEV_(1)/FVC,partial pressure of carbon dioxide(PaCO_(2)),partial pressure of oxygen(PaO_(2)),traditional Chinese medicine syndrome score,modified version of British Medical Reseach COuncil respiratory questionnaire(mMRC)and COPD assessment test(CAT)between the two groups before treatment(P>0.05).After treatment,FEV_(1),FVC,FEV_(1),/FVC,and PaO_(2),in the two groups were higher than those before treatment,while PaCO_(2),traditional Chinese medicine syndrome scores,mMRC,and CAT scores were lower than those before treatment,with statistical significances(P<0.05).After treat-ment,the FEV_(1),FVC,FEV_(1),/FVC,and PaO_(2)in the observation group were higher than those in the control group,while Pa-CO2,traditional Chinese medicine syndrome scores,mMRC,and CAT scores were lower than those in the control group,with statisti

关 键 词：慢性阻塞性肺疾病 调补肺肾 揿针 六味地黄汤 

分 类 号：R563[医药卫生—呼吸系统]