阿司匹林肠溶片联合雌二醇凝胶在宫腔粘连术后患者中的应用效果及对AFS评分的影响  

Application effect of aspirin enteric-coated tablets combined with estradiol gel in patients with intrauterine adhesions after operation and its influence on AFS score

作　　者：郭美艳 刘丹 李名方 GUO Meiyan;LIU Dan;LI Mingfang(Gynecology and Obstetrics Department,Shenmu Hospital,Shenmu 719399;Gynecology Department,No.215 Hospital of Shaanxi Nuclear Industry,Xianyang 712000;Gynecology and Obstetrics Department,the People's Hospital of Sichuan Provincial,Chengdu 610072,China)

机构地区：[1]神木市医院妇产科,陕西神木719399 [2]陕西省核工业二一五医院妇科,陕西咸阳712000 [3]四川省人民医院妇产科,四川成都610072

出　　处：《临床医学研究与实践》2024年第22期44-47,共4页Clinical Research and Practice

基　　金：四川省保健委员会2020年干部保健科研课题(川干研2020-637)。

摘　　要：目的探讨阿司匹林肠溶片联合雌二醇凝胶在宫腔粘连术后患者中的应用效果及对美国生育学会(AFS)评分的影响。方法选取2021年1月至2022年1月接受手术治疗的81例宫腔粘连患者作为研究对象,根据随机数字表法将其分为对照组(40例)和观察组(41例)。对照组术后给予雌二醇凝胶治疗,观察组在对照组基础上给予阿司匹林肠溶片治疗。比较两组的治疗效果。结果观察组的治疗总有效率为97.56%,高于对照组的85.00%(P<0.05)。治疗后,两组的子宫内膜厚度增加,子宫动脉搏动指数(PI)和阻力指数(RI)降低,且观察组优于对照组(P<0.05)。治疗后,两组的AFS各维度评分及总分均降低,且观察组低于对照组(P<0.05)。观察组的宫腔再粘连发生率为2.44%,低于对照组的15.00%(P<0.05);观察组的妊娠率为41.46%,高于对照组的20.00%(P<0.05)。结论阿司匹林肠溶片联合雌二醇凝胶用于宫腔粘连术后患者的效果较好,可增加子宫内膜厚度,改善子宫动脉血流,促进子宫内膜恢复,降低宫腔再次粘连发生率,提升妊娠率。Objective To investigate the application effect of aspirin enteric-coated tablets combined with estradiol gel in patients with intrauterine adhesions after operation and its influence on American Fertility Society(AFS)score.Methods A total of 81 patients with intrauterine adhesions who underwent surgical treatment from January 2021 to January 2022 were selected as the study subjects,the patients were divided into control group(40 cases)and observation group(41 cases)by random number table method.The control group was treated with estradiol gel after operation,and the observation group was treated with aspirin enteric-coated tablets on the basis of the control group.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was 97.56%,which was higher than 85.00%in the control group(P<0.05).After treatment,the endometrial volume thickness of the two groups increased,and the pulsatility index(PI)and resistance index(RI)of the uterine artery decreased,and those in the observation group were better than the control group(P<0.05).After treatment,the each dimension of AFS scores and the total score of the two groups decreased,and those of the observation group were lower than the control group(P<0.05).The incidence of intrauterine re-adhesion in the observation group was 2.44%,which was lower than 15.00%in the control group(P<0.05);the pregnancy rate in the observation group was 41.46%,which was higher than 20.00%in the control group(P<0.05).Conclusion The aspirin enteric-coated tablets combined with estradiol gel have a higher effect on patients with intrauterine adhesions,which can increase endometrial thickness,improve uterine artery blood flow,promote endometrial recovery,reduce the incidence of intrauterine re-adhesions,and improve pregnancy rate.

关 键 词：阿司匹林肠溶片 雌二醇凝胶 宫腔粘连 

分 类 号：R713.4[医药卫生—妇产科学]