精准胆道外科理论引导下手术治疗胆囊癌的效果及对应激反应、肿瘤标志物水平的影响  

Effect of surgical treatment of gallbladder cancer under the guidance of precise biliary tract surgery theory and its influences on stress response and tumor marker level

作　　者：周永纲 高艳霞 王秦玉 ZHOU Yonggang;GAO Yanxia;WANG Qinyu(the First People's Hospital of Xianyang,Xianyang 712000;No.215 Hospital of Shaanxi Nuclear Industry,Xianyang 712000,China)

机构地区：[1]咸阳市第一人民医院,陕西咸阳712000 [2]陕西省核工业二一五医院,陕西咸阳712000

出　　处：《临床医学研究与实践》2024年第22期72-75,共4页Clinical Research and Practice

基　　金：陕西省核工业二一五医院2020年院级科研立项项目(No.215KYJJ-202013)。

摘　　要：目的分析精准胆道外科理论引导下手术治疗胆囊癌的效果及对应激反应、肿瘤标志物水平的影响。方法选择2020年1月至2022年2月医院收治100例胆囊癌患者为研究对象,以随机数字表法将其分为对照组、观察组,每组50例。对照组采用传统胆囊根治术治疗,观察组给予精准胆道外科理论引导下手术治疗。比较两组的治疗效果。结果观察组的手术时长长于对照组,术中出血量少于对照组,淋巴结清扫数量多于对照组,首次排气时间、住院时间短于对照组(P<0.05)。术后24 h,观察组的促肾上腺皮质激素(ACTH)、皮质醇(Cor)水平低于对照组(P<0.05)。术后2周,观察组的癌胚抗原(CEA)、糖类抗原125(CA125)及甲胎蛋白(AFP)水平低于对照组(P<0.05)。结论精准胆道外科理论引导下手术治疗胆囊癌不仅可缓解机体应激反应,调节肿瘤标志物水平,还有助于提升手术效果,缩短患者住院时间,值得推广。Objective To analyze the effect of surgical treatment of gallbladder cancer under the guidance of precise biliary surgery theory and its influences on stress response and tumor marker level.Methods A total of 100 patients with gallbladder cancer admitted in hospital from January 2020 to February 2022 were selected as the research objects,and the patients were divided into control group and observation group by random number table method,with 50 cases in each group.The control group was treated with traditional radical cholecystectomy,and the observation group was treated with surgery under the guidance of precise biliary tract surgery theory.The therapeutic effects of the two groups were compared.Results The operation time of the observation group was longer than that of the control group,the intraoperative blood loss was less than that of the control group,the number of lymph node dissection was more than that of the control group,and the first exhaust time and hospitalization time were shorter than those of the control group(P<0.05).At 24 h after operation,the levels of adrenocorticotropic hormone(ACTH)and cortisol(Cor)in the observation group were lower than those in the control group(P<0.05).At 2 weeks after operation,the levels of carcinoembryonic antigen(CEA),carbohydrate antigen 125(CA125)and alpha fetoprotein(AFP)in the observation group were lower than those in the control group(P<0.05).Conclusion The surgical treatment of gallbladder cancer under the guidance of precise biliary tract surgery theory can not only alleviate the bodys'stress response,regulate the level of tumor markers,but also help to improve the surgical effect and shorten the hospitalization time of patients,which is worthy of promotion.

关 键 词：精准胆道外科理论 胆囊癌 应激反应 肿瘤标志物 

分 类 号：R657.4[医药卫生—外科学]