阿卡波糖联合骨化三醇、钙剂治疗2型糖尿病伴骨质疏松症的效果及对骨代谢的影响  

Effect of acarbose combined with calcitriol and calcium in the treatment of type 2 diabetes mellitus with osteoporosis and its influence on bone metabolism

作　　者：冯朵 FENG Duo(Xingyuan Hospital of Yulin,Yulin 719000,China)

机构地区：[1]榆林市星元医院,陕西榆林719000

出　　处：《临床医学研究与实践》2024年第22期88-91,共4页Clinical Research and Practice

摘　　要：目的分析阿卡波糖联合骨化三醇、钙剂治疗2型糖尿病伴骨质疏松症的效果及对骨代谢的影响。方法选取2020年6月至2022年6月我院收治的90例2型糖尿病伴骨质疏松症患者,以随机数字表法将其分为对照组和观察组,各45例。对照组采用胰岛素联合骨化三醇、钙剂治疗,观察组采用阿卡波糖联合骨化三醇、钙剂治疗。比较两组的治疗效果。结果观察组的治疗总有效率显著高于对照组(P<0.05)。治疗后,观察组的Ⅰ型胶原羧基端肽β特殊序列(β-CTX)、miR-144、NOD样受体蛋白3(NLRP3)m RNA表达及单核细胞趋化蛋白-1(MCP-1)水平低于对照组,骨钙素(OC)、骨特异性碱性磷酸酶(B-ALP)水平及Ward's三角、L_(1~4)的骨密度高于对照组(P<0.05)。结论阿卡波糖联合骨化三醇、钙剂治疗2型糖尿病伴骨质疏松症能提高疗效,促进患者骨代谢改善和骨密度提高,也能下调miR-144、NLRP3 m RNA及MCP-1表达。Objective To analyze the effect of acarbose combined with calcitriol and calcium in the treatment of type 2 diabetes mellitus with osteoporosis and its influence on bone metabolism.Methods A total of 90 patients with type 2 diabetes mellitus and osteoporosis admitted in our hospital from June 2020 to June 2022 were selected and divided into control group and observation group by random number table method,with 45 cases in each group.The control group was treated with insulin combined with calcitriol and calcium,and the observation group was treated with acarbose combined with calcitriol and calcium.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was significantly higher than that in the control group(P<0.05).After treatment,the level of typeⅠcollagen carboxy-terminal peptide β-specific sequence(β-CTX),expression of miR-144,NOD-like receptor protein 3(NLRP3)mRNA and monocyte chemotactic protein-1(MCP-1)level in the observation group were lower than those in the control group,and the levels of osteocalcin(OC),bone-specific alkaline phosphatase(B-ALP),and bone mineral density of Ward's triangle and L_(1-4 )were higher than those in the control group(P<0.05).Conclusion Acarbose combined with calcitriol and calcium in the treatment of type 2 diabetes mellitus with osteoporosis can improve the curative effect,promote the improvement of bone metabolism and bone mineral density,and also down-regulate the expression of miR-144,NLRP3 mRNA and MCP-1.

关 键 词：阿卡波糖 骨化三醇 钙剂 2型糖尿病 骨质疏松症 骨代谢 

分 类 号：R587.1[医药卫生—内分泌]