含连翘中成药组方用药规律的数据挖掘分析  

Data mining analysis of prescription medication rules of Chinese patent medicine containing Forsythia suspensa

作　　者：张晓菁 闫晓霞 牛宇龙[1] 史琳婧[1] 齐娜娜 马保连 ZHANG Xiaojing;YAN Xiaoxia;NIU Yuong;SHI Linjing;QI Nana;MA Baolian(Changzhi Medical College,Changzhi 046000,China)

机构地区：[1]长治医学院,山西长治046000

出　　处：《临床医学研究与实践》2024年第22期124-128,共5页Clinical Research and Practice

基　　金：山西省大学生创新创业训练计划项目(No.20230850);长治医学院博士科研启动基金项目(No.BS202012);长治医学院科技创新团队项目(No.CX202002)。

摘　　要：目的探讨含连翘中成药的组方用药规律,为连翘的临床用药及进一步开发提供依据。方法收集整理2020版《中国药典》《新编国家中成药》与《中华人民共和国卫生部药品标准·中药成方制剂》中含连翘的中成药处方并建立数据库,运用数据挖掘技术对其进行频次分析、关联分析和聚类分析,以探索含连翘中成药的组方用药规律。结果获得含连翘中成药处方183个,共涉及302味中药,出现频数较高的前5味中药依次为连翘、甘草、黄芩、薄荷和金银花。药性频数较高的为寒、温,药味频数较高的为苦、辛,归经以肺、胃常见。含连翘中成药处方中使用频数最多的为清热药,其次为解表药、补虚药、化痰止咳平喘药。含连翘中成药中剂型以丸剂、片剂居多。结论以连翘-金银花为代表的清热解毒类中药在含连翘的中成药中应用较多,主要用于治疗肺系病类,与现代药理学研究结果一致。Objective To explore the medication rules of Chinese patent me dicine containing Forsythia suspensa,and to provide the basis for the clinical medication and further development of Forsythia suspensa.Methods The prescriptions of Chinese patent medicine containing Forsythia suspensa in the 2020 edition of Chinese Pharmacopoeia,the New National Traditional Chinese Patent Medicines and Ministry of Health of the People's Republic of China Drug Standards·Traditional Chinese Medicine Prescription Preparation were collected and a database was established.Data mining technology was used to conduct frequency analysis,correlation analysis and cluster analysis to explore the prescription medication rules of Chinese patent medicine containing Forsythia suspensa.Results A total of 183 prescriptions of Chinese patent medicine containing Forsythia suspensa were obtained,involving 302 Chinese medicines,top five Chinese medicines with high frequency were Forsythia suspensa,Glycyrrhiza uralensis,Scutellaria baicalensis,Mentha haplocalyx and Lonicera japonica.The higher frequency of medicinal properties was cold and warm,and the higher frequency of medicinal taste was bitter and acrid,and the common channel tropism was lung and stomach.The most frequently used Chinese patent medicines containing Forsythia suspensa are heat-clearing drugs,followed by relieving drugs,tonic drugs,phlegm-resolving cough-relieving and asthma-relieving drugs.The dosage forms of Chinese patent medicines containing Forsythia suspensa were mostly pills and tablets.Conclusion Heat-clearing and detoxifying Chinese medicines represented by Forsythia suspensa-Lonicera japonica are widely used in Chinese patent medicines containing Forsythia suspensa,mainly for the treatment of pulmonary diseases,which is consistent with the results of modern pharmacological research.

关 键 词：连翘 中成药 用药规律 

分 类 号：R254[医药卫生—中医内科学]