生脉饮合沙参麦冬汤加味对非小细胞肺癌患者生活质量及CEA、ERCC1、K-ras与GP-73水平的影响  

Effects of modified Shengmai Yin combined with Shashen Maidong decoction on quality of life and levels of CEA,ERCC1,K-ras and GP-73 in patients with non-small cell lung cancer

作　　者：吴娟娟 寇凯鹏 WU Juanjuan;KOU Kaipeng(People's Hospital of Tongchuan,Tongchuan 727000,China)

机构地区：[1]铜川市人民医院,陕西铜川727000

出　　处：《临床医学研究与实践》2024年第22期134-137,共4页Clinical Research and Practice

摘　　要：目的探讨生脉饮合沙参麦冬汤加味对非小细胞肺癌(NSCLC)患者生活质量及癌胚抗原(CEA)、核苷酸切除修复交叉互补组1(ERCC1)、鼠类肉瘤病毒癌基因(K-ras)与高尔基体糖蛋白-73(GP-73)水平的影响。方法选取2020年3月至2022年3月我院收治的102例NSCLC患者为研究对象,将其随机分为对照组和观察组,各51例。对照组采用常规西药治疗,观察组在对照组基础上采用生脉饮合沙参麦冬汤加味治疗。比较两组的治疗效果。结果观察组的疾病缓解率高于对照组(P<0.05)。治疗后,观察组的CD3^(+)、CD4^(+)及CD4^(+)/CD8^(+)高于对照组(P<0.05)。观察组的不良反应总发生率低于对照组(P<0.05)。治疗后,观察组的CEA、ERCC1、K-ras及GP-73水平低于对照组(P<0.05)。治疗后,观察组的(FACT-G)各维度评分高于对照组(P<0.05)。结论生脉饮合沙参麦冬汤加味治疗NSCLC可提高患者的临床疗效及免疫功能,并减少不良反应,降低血清标记蛋白水平,进而改善生活质量,值得临床推广。Objective To investigate the effects of modified Shengmai Yin combined with Shashen Maidong decoction on the quality of life and the levels of carcinoembryonic antigen(CEA),excision repair cross complementing 1(ERCC1),Kirsten rat sarcoma viral oncogene(K-ras)and Golgi protein-73(GP-73)in patients with non-small cell lung cancer(NSCLC).Methods A total of 102 patients with NSCLC admitted in our hospital from March 2020 to March 2022 were selected as the research objects,the patients were randomly divided into control group and observation group,with 51 cases in each group.The control group was treated with conventional western medicine,and the observation group was treated with modified Shengmai Yin combined with Shashen Maidong decoction on the basis of the control group.The therapeutic effects of the two groups were compared.Results The disease remission rate of the observation group was higher than that of the control group(P<0.05).After treatment,the CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)in the observation group were higher than those in the control group(P<0.05).The total incidence of adverse reactions in the observation group was lower than that in the control group(P<0.05).After treatment,the levels of CEA,ERCC1,K-ras and GP-73 in the observation group were lower than those in the control group(P<0.05).After treatment,the scores of each dimension of Functional Assessment of Cancer Therapy-General(FACT-G)in the observation group were higher than those in the control group(P<0.05).Conclusion Modified Shengmai Yin combined with Shashen Maidong decoction in the treatment of NSCLC can improve the clinical efficacy and immune function of patients,reduce the adverse reactions,decrease the levels of serum marker protein,and then improve the quality of life,which is worthy of clinical promotion.

关 键 词：生脉饮 沙参麦冬汤 非小细胞肺癌 血清标记蛋白 

分 类 号：R256.1[医药卫生—中医内科学]