血浆NT-proBNP、TyG联合CAAP-AF评分预测AF患者射频消融术后复发的价值研究  

Value Research of Plasma NT-proBNP,TyG Combined with CAAP-AF Score in Predicting Recurrence After Radiofrequency Ablation in AF Patients

作　　者：熊晨 陈小丹 颜凤玲 XIONG Chen;CHEN Xiaodan;YAN Fengling(Department of Cardiowusculur Medicine,General Hospital of Central Theater Command,Wuhan Hubei 430070,China)

机构地区：[1]中部战区总医院心血管内科,湖北武汉430070

出　　处：《联勤军事医学》2024年第5期408-411,437,共5页Military Medicine of Joint Logistics

摘　　要：目的 分析血浆氨基末端B型脑铀肤前体(nitrogenterminal B type natriureticpep旬出precursor, NT-proBNP)、甘油三醋葡萄糖指数(triglyceride glucose index, TyG)联合冠状动脉粥样硬化性心脏病-年份-心房内径-阵发性房颤评分系统(coronary heart disease age atrial diameter paroxysmal atrial fibrillation scoring system, CAAP-AF)预测心房颤动(atrial fibrillation, AF)患者射顿消融术后复发的临床价值。方法 226例AF患者根据射频消融术后3个月内是否发生AF复发分为复发组(n=31)和未复发组(n=195)。比较两组AF患者年龄、性别、体质量指数(body mass index, BMI)、心功能分级、基础性疾病[冠状动脉粥祥硬化性心脏病(以下简称为冠心病)、高血压、2型糖尿病]、吸烟史、饮酒史等临床资料,检测血浆NT-proBNP表达水平及计算TyG,同时进行CAAP-AF评分系统评估。采用多因素Logistic回归分析探讨影响AF患者射频消融术后复发的独立危险因素,采用受试看工作特征(receiver operating characteristic, ROC)曲线分析血浆NT-proBNP、TyG联合CAAP-AF评分预测AF患者射频消融术后复发的临床价值。结果 复发组AF患者血浆NT-proBNP表达水平、TyG及CAAP-AF评分均高于未复发组,差异有统计学意义(P均<0.01)。血浆NT-proBNP,TyG及CAAP-AF评分均为影响AF患者射频消融术后复发的独立危险因素(P<0.05)。血浆NT-proBNP、TyG联合CAAP-AF预测AF患者射频消融术后复发的曲线下面积(area under the curve, AUC)为0.829、灵敏度为90.32%,特异度为81.03%,预测价值较高,且均优于血浆NT-proBNP,TyG、CAAP-AF单一指标的预测价值(P<0.05)。结论 血浆NT-proBNP,TyG联合CAAP-AF预测AF患者射频消融术后复发具有较好的临床应用价值,可作为临床预测AF患者射频消融术后复发的参考指标。Objective To analyze the clinical value of plasma nitrogenterminal B type natriureticpeptide precursor(NT-proBNP),triglyceride-glucose index(TyG)combined with coronary heart disease age atrial diameter paroxysmal at-rial fibrillation scoring system(CAAP-AF)in predicting recurrence after radiofrequency ablation in patients with atrial fi-brillation(AF).Methods A total of 226 patients with AF were divided into recurrent group(n=31)and non-recurrent group(n=195)according to whether AF recurred within 3 months after radiofrequency ablation.The clinical data such as age,sex,body mass index(BMI),cardiac function classification,basic diseases(coronary heart disease,hypertension,type 2 diabetes mellitus),smoking history and drinking history of AF patients between the two groups were compared,the expression levels of plasma NT-proBNP were detected,TyG was calculated,and the CAAP-AF scoring system was evaluated.The independent risk factors for the recurrence after radiofrequency ablation in AF patients were investigated by multivariate Logistic regression,and the clinical value of plasma NT-proBNP,TyG combined with CAAP-AF scores in predicting the recurrence after radiofrequency ablation in AF patients was analyzed by receiver operating characteristic(ROC)curve.Results The expression levels of plasma NT-proBNP,TyG and CAAP-AF scores of AF patients in the recurrence group were higher than those in the non-recurrent group,and the difference was statistically significant(all P<0.01).The plasma NT-proBNP,TyG and CAAP-AF scores were independent risk factors for recurrence after radiofre-quency ablation in AF patients(P<0.05).The area under the curve(AUC),sensitivity and specificity of plasma NT-proBNP,TyG combined with CAAP-AF in predicting the recurrence after radiofrequency ablation in AF patients were 0.829,90.32%and 81.03%respec-tively,which had high predictive value and were better than single indexes of plasma NT-proBNP,TyG and CAAP-AF(P<0.05).Conclusion The detection of plasma NT-proBNP and TyG combined with CAAP-AF has

关 键 词：氨基末端脑钠肽前体 甘泊三酯葡萄糖指数 冠状动脉粥样硬化性心脏病-年龄-心房内径-阵发性房颤评分系统 心房颤动 射频消融术 

分 类 号：R541.75[医药卫生—心血管疾病]