焦虑抑郁孕妇的孕晚期唾液皮质醇水平与新生儿出生体重的相关性  

The association between salivary cortisol level in the third trimester and neonatal birth weight among women with anxiety and depression

作　　者：王秋萍 骆淑娟 江楠 范余娟 WANG Qiu-ping;LUO Shu-juan;JIANG-Nan;FAN Yu-juan(Department of Obstetrics,Shenzhen Guangming District People′s Hospital,Shenzhen 518107,Guangdong,China)

机构地区：[1]深圳市光明区人民医院产科,广东深圳518107 [2]深圳市光明区人民医院精神卫生科,广东深圳518107

出　　处：《广东医学》2024年第7期813-818,共6页Guangdong Medical Journal

基　　金：深圳市科技计划(JCYJ20190813173601664);深圳市光明区科技计划(2020R01051)。

摘　　要：目的评估焦虑抑郁母亲对新生儿出生体重的影响,探究孕晚期唾液皮质醇水平与新生儿出生体重的相关性。方法2021年1—12月期间在深圳市光明区人民医院产科门诊就诊的早孕期单胎妊娠孕妇,对其进行焦虑抑郁评估。有40例焦虑抑郁孕妇作为观察组和同期就诊的50例正常孕妇作为对照组,在孕晚期检测唾液皮质醇水平和睡眠情绪测评。比较两组的唾液皮质醇水平和分娩结局,并分析唾液皮质醇水平和新生儿出生体重的相关性。结果观察组抑郁孕妇的唾液皮质醇水平显著高于正常孕妇,差异有统计学意义(P<0.001),两组间的新生儿出生孕周和体重差异无统计学意义(P>0.05),但观察组的剖宫产率显著高于对照组,差异有统计学意义(57.5%vs.24.0%)。孕晚期的唾液皮质醇水平和出生体重呈负相关,但无统计学意义(P>0.05)。结论焦虑抑郁孕妇在妊娠晚期的唾液皮质醇呈现高水平,他们有更高的剖宫产率,未发现唾液皮质醇水平与新生儿出生体重的相关性。Objective To evaluate the impact of anxiety and depression in mothers on newborn birth weight and explore the correlation between late pregnancy salivary cortisol levels and newborn birth weight.Methods Pregnant women with singleton pregnancies who attended the obstetrics outpatient department of the Shenzhen Guangming District People′s Hospital from January to December,2021 were assessed for anxiety and depression.Forty pregnant women with anxiety and depression were selected as the case group,and 50 normal pregnant women who attended during the same period were selected as the control group.Salivary cortisol levels and sleep emotion assessments were performed in the late pregnancy period.The salivary cortisol levels and delivery outcomes were compared between the two groups,and the correlation between salivary cortisol levels and newborn birth weight was analyzed.Results The salivary cortisol levels of pregnant women with depression and anxiety in the case group were significantly higher than those in the control group(P<0.001).There was no significant difference in gestational age and birth weight between the two groups(P>0.05),but the rate of cesarean section in the case group was significantly higher than that in the control group(57.5%vs.24.0%).Salivary cortisol levels in late pregnancy were negatively correlated with birth weight,but the correlation was not significant(P>0.05).Conclusion Pregnant women with anxiety and depression have elevated levels of salivary cortisol in late pregnancy and a higher rate of cesarean section.No correlation was found between salivary cortisol levels and newborn birth weight.

关 键 词：产前焦虑抑郁 唾液皮质醇 新生儿 出生体重 

分 类 号：R714.51[医药卫生—妇产科学] R714.7[医药卫生—临床医学]