2009—2023年中国16个省份急性呼吸道感染病例中人呼吸道合胞病毒的流行特征分析  

Epidemiological characteristics of human respiratory syncytial virus among acute respiratory infection cases in 16 provinces of China from 2009 to 2023

作　　者：崔爱利[1] 夏百成 朱贞[1] 谢智博 孙利伟[2] 徐瑾[3] 许晶[4] 李忠[5] 赵林清[6] 龙晓茹 于德山[8] 朱冰 张凤 穆敏[11] 谢会 蔡亮[13] 朱云[14] 田晓灵 王冰[16] 郜振国[17] 刘晓庆[18] 任斌知[19] 韩光跃[20] 胡孔新[21] 张燕[1] Cui Aili;Xia Baicheng;Zhu Zhen;Xie Zhibo;Sun Liwei;Xu Jin;Xu Jing;Li Zhong;Zhao Linqing;Long Xiaoru;Yu Deshan;Zhu Bing;Zhang Feng;Mu Min;Xie Hui;Cai Liang;Zhu Yun;Tian Xiaoling;Wang Bing;Gao Zhenguo;Liu Xiaoqing;Ren Binzhi;Han Guangyue;Hu Kongxin;Zhang Yan(National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases(NITFID)/NHC Key Laboratory of Medical Virology and Viral Diseases/National Institute for Viral Disease Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing 102206,China;Precision Medicine Research Center,Children′s Hospital of Changchun,Changchun 130061,China;Institute of Expanded Immunization Program,Henan Provincial Center for Disease Control and Prevention,Zhengzhou 450016,China;National Institute for Viral Disease Control and Prevention,Shaanxi Provincial Center for Disease Control and Prevention,Xi′an 710054,China;Institute for Communicable Disease Control and Prevention,Shandong Center for Disease Control and Prevention,Jinan 250014,China;Laboratory of Virology,Beijing Key Laboratory of Etiology of Viral Diseases in Children,Capital Institute of Pediatrics,Beijing 100020,China;Department of Infectious Diseases,Children′s Hospital Affiliated to Chongqing Medical University,Chongqing 400014,China;Institute of Pathogen Testing,Gansu Provincial Center for Disease Control and Prevention,Lanzhou 730000,China;Virus Laboratory,Guangzhou Women and Children′s Medical Center,Guangzhou Medical University,Guangzhou 510120,China;Aboratory of Viral Diseases,Qingdao Municipal Centre for Disease Control and Prevention,Qingdao Institute of Prevention Medicine,Qingdao 266000,China;School of Public Health,Anhui University of Science and Technology,Huainan 232001,China;Institute for Immunization and Prevention,Beijing Center for Disease Prevention and Control,Beijing Academy for Preventive Medicine,Beijing Institute of Tuberculosis Control Research and Prevention,Beijing 100013,China;Hunan Provincial Center for Disease Control and Prevention,Changsha 410

机构地区：[1]传染病溯源预警与智能决策全国重点实验室、国家卫生健康委医学病毒和病毒病重点实验室、中国疾病预防控制中心病毒病预防控制所,北京102206 [2]长春市儿童医院精准医学研究中心,长春130061 [3]河南省疾病预防控制中心免疫预防与规划所,郑州450016 [4]陕西省疾病预防控制中心病毒病预防控制所,西安710054 [5]山东省疾病预防控制中心传染病预防控制所,济南250014 [6]首都儿科研究所,病毒学研究室,儿童病毒病病原学北京市重点实验室,北京100020 [7]重庆医科大学附属儿童医院感染科,重庆400014 [8]甘肃省疾病预防控制中心病原检测所,兰州730000 [9]广州市妇女儿童医疗中心病毒研究室,广州510120 [10]青岛市疾病预防控制中心(青岛市预防医学研究院)病毒性疾病检验所,青岛266000 [11]安徽理工大学公共卫生学院,淮南232001 [12]北京市疾病预防控制中心(北京市预防医学科学院、北京结核病控制研究与防治所)免疫预防所,北京100013 [13]湖南省疾病预防控制中心,长沙410005 [14]国家儿童医学中心,首都医科大学附属北京儿童医院,感染与病毒研究室,北京100045 [15]内蒙古自治区综合疾病预防控制中心免疫规划所,呼和浩特010000 [16]沈阳市疾病预防控制中心传染病防制所,沈阳110000 [17]新疆维吾尔自治区疾病预防控制中心传染病防治所,乌鲁木齐830002 [18]江西省疾病预防控制中心疾病控制检验所重大新发突发病毒性传染病江西省卫生健康重点实验室,南昌330029 [19]山西省疾病预防控制中心疾病检验科,太原030012 [20]河北省疾病预防控制中心病毒所,石家庄050021 [21]中国检验检疫科学研究院卫生检验与检疫研究所,北京100123

出　　处：《中华预防医学杂志》2024年第7期945-951,共7页Chinese Journal of Preventive Medicine

基　　金：国家科技重大专项课题(2018ZX10713002);国家卫健委重大公共卫生疾控专项(ZDGW21-131031103000180005)。

摘　　要：目的了解2009—2023年我国16个省份急性呼吸道感染(ARI)病例中人呼吸道合胞病毒(HRSV)的流行特征。方法研究资料来源于2009—2023年我国16个省份ARI病例监测数据,共有28 278例ARI病例纳入研究。监测病例的临床标本进行了HRSV核酸筛查,并分析不同年龄组、不同地区和不同月份病例的HRSV检出率差异。结果 2009年1月至2023年9月,共纳入28 278例ARI病例。病例年龄范围为<1月龄~112岁,年龄M(Q1,Q3)为3岁(1岁,9岁)。28 278例ARI病例中有3 062例HRSV核酸阳性,总检出率为10.83%。2009—2019年HRSV检出率为9.33%,病毒主要以冬春季流行为主。在新型冠状病毒感染(COVID-19)流行期间,HRSV检出率在6.32%~18.67%之间波动;2022年底至2023年初未出现HRSV传统的冬季流行高峰,在2023年4—5月出现了HRSV反季节流行。87.95%(2 693/3 062)HRSV阳性病例为 5岁以下的儿童,不同年龄组中HRSV检出率的差异具有统计学意义(P<0.001),呈现出随着年龄增加HRSV检出率降低的趋势(P<0.001),其中以<6月龄组患儿的HRSV检出率最高(25.69%)。和2009—2019年相比,2020—2023年期间不同年龄组的HRSV检出率从高到低的排序发生变化,HRSV阳性病例的年龄M(Q1,Q3)从1岁(6月龄,3岁)增加至2岁(11月龄,3岁)。结论通过连续15年的HRSV监测分析发现,5岁以下的儿童,尤其是<6月龄婴幼儿是HRSV感染的主要高发人群。COVID-19流行期间,我国HRSV流行水平和流行模式发生了变化。Objective To understand the epidemiological characteristics of human respiratory syncytial virus(HRSV)among acute respiratory infection(ARI)cases in 16 provinces of China from 2009 to 2023.Methods The data of this study were collected from the ARI surveillance data from 16 provinces in China from 2009 to 2023,with a total of 28278 ARI cases included in the study.The clinical specimens from ARI cases were screened for HRSV nucleic acid from 2009 to 2023,and differences in virus detection rates among cases of different age groups,regions,and months were analyzed.Results A total of 28278 ARI cases were enrolled from January 2009 to September 2023.The age of the cases ranged from<1 month to 112 years,and the age M(Q1,Q3)was 3 years(1 year,9 years).Among them,3062 cases were positive for HRSV nucleic acid,with a total detection rate of 10.83%.From 2009 to 2019,the detection rate of HRSV was 9.33%,and the virus was mainly prevalent in winter and spring.During the Corona Virus Disease 2019(COVID-19)pandemic,the detection rate of HRSV fluctuated between 6.32%and 18.67%.There was no traditional winter epidemic peak of HRSV from the end of 2022 to the beginning of 2023,and an anti-seasonal epidemic of HRSV occurred from April to May 2023.About 87.95%(2693/3062)of positive cases were children under 5 years old,and the difference in the detection rate of HRSV among different age groups was statistically significant(P<0.001),showing a decreasing trend of HRSV detection rate with the increase of age(P<0.001).Among them,the HRSV detection rate(25.69%)was highest in children under 6 months.Compared with 2009-2019,the ranking of HRSV detection rates in different age groups changed from high to low between 2020 and 2023,with the age M(Q1,Q3)of HRSV positive cases increasing from 1 year(6 months,3 years)to 2 years(11 months,3 years).Conclusion Through 15 years of continuous HRSV surveillance analysis,children under 5 years old,especially infants under 6 months old,are the main high-risk population for HRSV infection.During the COVI

关 键 词：人呼吸道合胞病毒 急性呼吸道感染 流行特征 监测 

分 类 号：R511[医药卫生—内科学] R181.3[医药卫生—临床医学]