产前空气污染物暴露与子代尿道下裂关联的研究进展  

Research progress on the association between prenatal exposure to air pollutants and hypospadias in the offspring

作　　者：徐岚静 郭静 钟朱淳 汤辰珺 施小明 陈光弟[1,3] Xu Lanjing;Guo Jing;Zhong Zhuchun;Tang Chenjun;Shi Xiaoming;Chen Guangdi(Department of Public Health,Zhejiang University School of Medicine,Hangzhou 310058,China;China CDC Key Laboratory of Environment and Population Health,National Institute of Environmental Health,Chinese Center for Disease Control and Prevention,Beijing 100021,China;Women's Hospital,School of Medicine Zhejiang University,Hangzhou 310003,China)

机构地区：[1]浙江大学医学院公共卫生学院,杭州310058 [2]中国疾病预防控制中心环境与人群健康重点实验室环境与健康相关产品安全所,北京100021 [3]浙江大学医学院附属妇产科医院,杭州310003

出　　处：《中华预防医学杂志》2024年第7期1082-1086,共5页Chinese Journal of Preventive Medicine

基　　金：浙江省卫生创新人才培养项目(2020-18)。

摘　　要：近年来,越来越多的流行病学研究显示,孕妇暴露于空气污染物(如空气颗粒物、氮氧化物、臭氧、二氧化硫等)增加子代先天性心脏病、神经管缺、唇腭裂以及尿道下裂等出生缺陷的发生风险。其中尿道下裂不仅会损害新生儿性功能,且在新生儿成长过程中带来严重的社会心理问题,因此,新生儿尿道下裂防治具有重大的公共卫生意义。然而,产前空气污染暴露与子代尿道下裂之间关联仍有争议。本文综述产前母体暴露于空气颗粒物、氮氧化物、臭氧、二氧化硫等空气污染物与子代尿道下裂的流行病学研究进展以及潜在的生物学机制,总结既往研究的局限性并展望未来研究方向,为孕产妇营造健康生活环境,降低子代尿道下裂发生风险提供科学依据。Recent epidemiological studies have increasingly found that pregnant women who are exposed to air pollutants(for example airborne particulate matter,nitrogen oxides,ozone,and sulfur dioxide)increase the risk of various birth defects in their offspring,such as congenital heart disease,neural tube defects,cleft lip and palate,and hypospadias.Hypospadias not only impairs the sexual function of infants but also causes major social and psychological problems during their growth period,therefore,the prevention and treatment of hypospadias infant carry substantial public health importance.However,the association between prenatal exposure to air pollution and hypospadias remains controversial.The study reviews the epidemiological research progress and potential biological mechanisms of prenatal maternal exposure to air pollutants such as particulate matter,nitrogen oxides,ozone,sulfur dioxide,and the risk of hypospadias in offspring.The study also summarizes the limitations of previous research and looks forward to future research directions,to provide scientific evidence for creating a healthy living environment for pregnant women,and reducing the risk of hypospadias in offspring.

关 键 词：空气污染物 尿道下裂 空气颗粒物 产前 流行病学研究 

分 类 号：R714[医药卫生—妇产科学]