介电润湿数字微流控技术在疾病诊断及预防领域的研究进展  

Advances in electrowetting-on-dielectric digital microfluidics technology for disease diagnosis and prevention applications

作　　者：朱文杰 王丽[2] 夏伟 王西龙 金晶 王鑫 陆艺 陈莹 Zhu Wenjie;Wang Li;Xia Wei;Wang Xilong;Jin Jing;Wang Xin;Lu Yi;Chen Ying(School of Medical Technology,Xuzhou Medical University,Xuzhou 221004,China;Department of Clinical Laboratory,Xuzhou First People′s Hospital,Xuzhou 221116,China;Nanjing RealMind Biotech Co.,Ltd.,Nanjing 210046,China;School of Biological Science and Medical Engineering,Southeast University,Nanjing 210096,China)

机构地区：[1]徐州医科大学医学技术学院,徐州221004 [2]徐州市第一人民医院检验科,徐州221116 [3]南京仁迈生物科技有限公司,南京210046 [4]东南大学生物科学与医学工程学院,南京210096

出　　处：《中华预防医学杂志》2024年第7期1087-1095,共9页Chinese Journal of Preventive Medicine

基　　金：江苏省自然科学基金(BK20231184);徐州市科技计划项目(KC22115);江苏省高校“青蓝工程”优秀青年骨干教师(2021年);江苏省科技副总项目(FZ20210142)。

摘　　要：快速精确诊断技术对于流行病预防和监控至关重要,基于介电润湿的数字微流控技术通过微量、灵活、高精度及并行性检测等优势,显著提升了其在疾病预防和个性化诊断方面的效率。本文阐述了介电润湿原理的数字微流控芯片工作原理,详细介绍了其在核酸、蛋白质及细胞检测等方面的最新研究进展,并对商业化的介电润湿数字微流控技术进行了简要梳理,最后讨论了该技术所面临的挑战以及未来发展方向。Rapid and accurate diagnostic technologies are crucial for early detection and diagnosis of diseases.Electrowetting-on-dielectric digital microfluidics,with its high-precision detection and high-throughput screening capabilities,significantly enhances the accuracy and efficiency in early disease diagnosis and personalized treatment,enabling swift disease detection and widespread screening.This article provides a comprehensive review of the working principles and fabrication processes of digital microfluidic chips based on electrowetting on dielectric method.It details the latest research progress in the areas of nucleic acids,proteins,and cells,organizes the commercialization of digital microfluidics technology,and finally discusses the current challenges and future directions of digital microfluidic chips.

关 键 词：数字微流控芯片技术 介电润湿 疾病预防 临床应用 

分 类 号：R44[医药卫生—诊断学]