老年股骨粗隆间骨折患者血清高密度脂蛋白水平与深静脉血栓形成的相关性  

The Correlation Between Serum High-Density Lipoprotein Level and Deep Vein Thrombosis in Elderly Patients with Intertrochanteric Fracture for Femur

作　　者：排合日丁·卡米力江 安外尔·阿皮孜 李建[1] 杨春波[1] 柴瑞峰[1] Paiherier·KAMILIJIANG;Anwaier·APIZI;LI Jian;YANG Chunbo;CHAI Ruifeng(Department of critical care medicine,The first affiliated hospital of Xinjiang medical university,Wulumuqi,Xinjiang 830054)

机构地区：[1]新疆医科大学第一附属医院重症医学一科,新疆乌鲁木齐830054

出　　处：《中国伤残医学》2024年第7期1-4,共4页Chinese Journal of Trauma and Disability Medicine

基　　金：新疆维吾尔自治区自认科学基金(2020D01C233)。

摘　　要：目的:探讨老年股骨粗隆间骨折患者血清高密度脂蛋白(HDL-C)水平与深静脉血栓(DVT)形成的相关性。方法:回顾性分析该院2019年9月-2022年9月收治的76例老年股骨粗隆间骨折术后患者资料,按是否发生DVT分为DVT组(n=8)与非DVT组(n=68)。术后2 d,检测所有患者的HDL-C水平并进行相关性分析。术后1个月,所有患者进行X线静脉造影检查,判断DVT的发生情况。对比2组血液流变学相关指标、凝血四项指标、患者基本情况及手术相关指标。结果:DVT组HDL-C水平低于非DVT组,D-二聚体高于非DVT组,组间差异有统计学意义(P<0.05)。DVT组纤维蛋白原高于非DVT组,差异有统计学意义(P<0.05)。Spearman相关分析显示HDL-C、D-二聚体、纤维蛋白原与DVT形成存在相关性(P<0.05)。非条件Logistic回归法显示HDL-C、D-二聚体、纤维蛋白原都为导致DVT形成的重要因素(P<0.05)。结论:老年股骨粗隆间骨折患者术后DVT的发生率较高,多伴随有血清HDL-C水平降低、血液流变学与凝血功能异常,老年股骨粗隆间骨折患者血清HDL-C水平与DVT形成存在相关性。Objective:To investigate the correlation between serum high density lipoprotein(HDL-C)level and deep vein thrombosis(DVT)in elderly patients with intertrochanteric fracture of femur.Methods:The data of 76 elderly patients with femoral intertrochanteric fracture treated in our hospital from September 2019 to September 2022 were retrospectively analysed,and were divided into DVT group(n=8)and non-DVT group(n=68)according to whether DVT occurred.X-ray venography was performed in all patients 1 month after operation to determine the occurrence of DVT.HDL-C levels were detected in all patients 2 days after surgery and correlation analysis was performed.The two groups were compared with hemorheological indicators,four coagulation indicators,patients’basic conditions and surgery related indicators.Results:The HDL-C level in DVT group was lower than that in non-DVT group,and the D-dimer was higher than that in non-DVT group,with statistical significance(P<0.05).The fibrinogen in DVT group was higher than that in non-DVT group,and the difference was statistically significant(P<0.05).Spearman correlation analysis showed that HDL-C,D-dimer and fibrinogen were correlated with DVT(P<0.05).Unconditional Logistic regression showed that HDL-C,D-dimer and fibrinogen were important factors leading to DVT(P<0.05).Conclusion:The incidence of DVT is higher in elderly patients with intertrochanteric fracture after operation,which is often accompanied by decreased HDL-C level,abnormal hemorheology and coagulation function.HDL-C level in elderly patients with intertrochanteric fracture of femur is correlated with DVT.

关 键 词：老年股骨粗隆间骨折 深静脉血栓形成 血清高密度脂蛋白 血液流变学 凝血功能 

分 类 号：R687.3[医药卫生—骨科学]