支气管哮喘并发肺部感染SP-D基因多态性、VCAM-1、MCP-1、TGF-β1水平  

SP-D gene polymorphism,VCAM-1,MCP-1 and TGF-β1 of bronchial asthma patients complicated with pulmonary infection

作　　者：闻明[1] 刘安静 杨立志 韦玲[3] 贾照英 纪明锁 WEN Ming;LIU An-jing;YANG Li-zhi;WEI Ling;JIA Zhao-ying;JI Ming-suo(Tianjin Teda Hospital,Tianjin 300457,China;不详)

机构地区：[1]天津市泰达医院感染疾病科,天津300457 [2]天津市滨海新区塘沽传染病医院呼吸科,天津300457 [3]天津市泰达医院急诊科,天津300457 [4]上海浦东新区公利医院内科,上海200237

出　　处：《中华医院感染学杂志》2024年第13期1954-1958,共5页Chinese Journal of Nosocomiology

基　　金：天津市科技计划基金资助项目(20ZXQXSY00050)。

摘　　要：目的探究支气管哮喘并发肺部感染患者表面活性蛋白-D(SP-D)基因多态性、血管细胞黏附分子-1(VCAM-1)、单核细胞趋化蛋白-1(MCP-1)、转化生长因子-β1(TGF-β1)变化及其与疾病进展的关系。方法回顾性选取2020年5月一2023年5月天津市泰达医院64例支气管哮喘并发肺部感染患者(感染组)与66例支气管哮喘未并发肺部感染患者(未感染组)的临床资料,感染组根据病情程度分为轻度感染组(38例)和中-重度感染组(26例)。检测SP-D基因多态性、血清VCAM-1、MCP-1、TGF-β1水平,Spearman相关性分析VCAM-1、MCP-1、TGF-β1与疾病进展的关系。结果感染组SP-D基因位点rs721917的TT基因型、T等位基因频率低于未感染组,CC基因型、C等位基因频率高于未感染组(P<0.05)。感染组血清VCAM-1、MCP-1、TGF-β1水平均高于未感染组(P<0.05)。中-重度感染组血清VCAM-1、MCP-1、TGF-β1水平均高于轻度感染组(P<0.05)。血清VCAM-1、MCP-1、TGF-β1水平与疾病进展呈正相关(P<0.05)。结论临床上支气管哮喘并发肺部感染患者及疾病进展与血清VCAM-1、MCP-1、TGF-β1水平异常升高有关,且SP-D基因多态性与支气管哮喘患者并发肺部感染有明显关系。OBJECTIVE To explore the changes of surfactant-D(SP-D),vascular cell adhesion molecule 1(VCAM-1),monocyte chemotactic protein-1(MCP-1)and transforming growth factor-β1(TGF-β1)in the bronchial asth-ma patients complicated with pulmonary infection and analyze the association with progression of disease.METHODS The clinical data were retrospectively collected from 64 bronchial asthma patients complicated with pulmonary infection(the infection group)and 66 bronchial asthma patients without pulmonary infection(the no infection group)who were treated in Tianjin Teda Hospital from May 2020 to May 2023.The patients of the in-fection group were divided into the mild infection group with 38 cases and the moderate-severe infection group with 26 cases according to the severity of disease.The SP-D gene polymorphism and the levels of serum VCAM-1,MCP-1 and TGF-β1 were detected.Spearman correlation analysis was performed for the relationship between VCAM-1,MCP-1,TGF-β1 and the progression of disease.RESULTS The frequencies of TT genotype and T allele at rs721917 locus of SP-D gene were significantly lower in the infection group than in the no infection group,while the frequencies of CC genotype and C allele were significantly higher in the infection group than in the no infection group(P<0.05).The levels of serum VCAM-1,MCP-1 and TGF-β1 of the infection group were significantly higher than those of the no infection group(P<0.05).The levels of serum VCAM-1,MCP-1 and TGF-β1 of the moderate-severe infection group were significantly higher than those of the mild infection group(P<0.05).The levels of serum VCAM-1,MCP-1 and TGF-β1 were positively correlated with the progression of disease(P<0.05).CONCLUSION The progression of disease of the bronchial asthma patients complicated with pulmonary infection is associated with abnormal rise of serum VCAM-1,MCP-1 and TGF-β1.There is significant relationship between the SP-D gene polymorphism and the pulmonary infection in the patients with bronchial asthma.

关 键 词：支气管哮喘 肺部感染 表面活性蛋白-D 血管细胞黏附分子-1 单核细胞趋化蛋白-1 转化生长因子-β1 基因多态性 

分 类 号：R562.25[医药卫生—呼吸系统]