子痫前期并发幽门螺杆菌感染血清miR-31-5p、miR-4286表达及意义  

Expressions of serum miR-31-5p and miR-4286 in preeclampsia pregnant women complicated with Helicobacter pylori infection and their significance

作　　者：苗丽晓 杨超[1] 马建彩[1] 张丽娜[1] 李瑞雪 杨丽萍[1] MIAO Li-xiao;YANG Chao;MA Jian-cai;ZHANG Li-na;LI Rui-xue;YANG Li-ping(Handan Central Hospital,Handan,Hebei 056004,China)

机构地区：[1]邯郸市中心医院产一科,河北邯郸056004

出　　处：《中华医院感染学杂志》2024年第13期2032-2036,共5页Chinese Journal of Nosocomiology

基　　金：河北省卫生健康委员会基金资助项目(20220553)。

摘　　要：目的分析子痫前期(PE)并发幽门螺杆菌(Hp)感染血清微小核糖核酸-31-5p(miR-31-5p)、微小核糖核酸-4286(miR-4286)表达及意义。方法将2022年1月-2023年5月邯郸市中心医院收治PE并发Hp感染孕妇198例纳入研究组,另择同期Hp感染的孕妇205例纳入对照组,随访至分娩。分析两组临床资料与妊娠结局、PE确诊时(T0)、妊娠28周第1天(T1)和妊娠30周第1天(T2)血清miR-31-5p、miR-4286表达水平,不同妊娠结局PE并发Hp感染孕妇不同时间点血清miR-31-5p、miR-4286表达水平,绘制受试者工作特征(ROC)曲线分析各项指标单独及联合检测对PE并发Hp感染孕妇不良妊娠结局的预测价值。结果相较对照组,研究组分娩方式剖宫产、妊娠结局不良比例更高,分娩孕周更短(P<0.05)。研究组T1、T2血清miR-4286水平低于对照组,血清miR-31-5p水平高于对照组(P<0.05)。各时间点PE并发Hp感染孕妇妊娠结局不良组血清miR-4286表达水平低于妊娠结局良好组,血清miR-31-5p表达水平高于妊娠结局良好组(P<0.05)。ROC曲线结果显示,联合检测各时间点指标的曲线下面积(AUC)最高为0.940(P<0.05),敏感度为86.61%,特异度为90.70%。结论PE并发Hp感染患者血清miR-31-5p表达水平更高,miR-4286表达水平更低,随着妊娠时间增加,血清miR-31-5p表达水平呈降低趋势,miR-4286表达水平呈升高趋势,联合检测各项指标对PE并发Hp感染患者不良妊娠结局具有较高的预测价值。OBJECTIVE To observe the expressions of serum microribonucleic acid-31-5p(miR-31-5p)and microri-bonucleic acid-4286(miR-4286)in the preeclampsia(PE)pregnant women complicated with Helicobacter pylori(Hp)infection and analyze the significance.METHODS A total of 198 PE pregnant women complicated with Hp infection who were treated in Handan Central Hospital from Jan 2022 to May 2023 were assigned as the study group,meanwhile,205 pregnant women with Hp infection were chosen as the control group.A follow-up was car-ried out till the delivery.The clinical data,pregnancy outcomes and expression levels of serum miR-31-5p and miR-4286 at the diagnosis of PE(TO),the first day of the 28th week of pregnancy(T1)and the first day of 30th week of pregnancy were observed and compared between the two groups;the expression levels of serum miR-31-5p and miR-4286 were compared among the PE pregnant women complicated with Hp infection with different pregnancy outcomes.The values of the single and joint detection of the indexes in prediction of poor pregnancy outcomes were analyzed by means of receiver operating characteristic(ROC)curves.RESULTS The proportions of pregnant women with cesarean section,poor pregnancy outcomes were significantly higher in the study group than in the control group,and the gestational age of the study group was significantly shorter than that of the control group(P<0.05).The serum miR-4286 level of the study group was significantly lower than that of the control group at T1 and T2,while the serum miR-31-5p level of the study group was significantly higher than that of the control group(P<0.05).Among the PE pregnant women complicated with Hp infection,the expression level of serum miR-4286 of the poor pregnancy outcome group was significantly lower than that of the favorable pregnancy outcome group at the time points,while the expression level of serum miR-31-5p of the poor pregnancy outcome group was significantly higher than that of the favorable pregnancy outcome group(P<0.05).The ROC curve analysis show

关 键 词：子痫前期 幽门螺杆菌 微小核糖核酸-31-5p 微小核糖核酸-4286 妊娠结局 预测价值 

分 类 号：R714.24[医药卫生—妇产科学]