Brain Mechanisms Underlying Panic Attack and Panic Disorder  

作　　者：Xuyan Guan Peng Cao 

机构地区：[1]Tsinghua Institute of Multidisciplinary Biomedical Research,Tsinghua University,Beijing,102206,China [2]National Institute of Biological Sciences(NIBS),Beijing,102206,China

出　　处：《Neuroscience Bulletin》2024年第6期795-814,共20页神经科学通报（英文版）

摘　　要：Panic disorder is a psychiatric disorder characterized by recurrent panic attacks,with a prevalence of~4%in the general population,causing heavy personal and socioeconomic burdens.The similarities of animal defense responses to clinical panic attack symptoms in humans make it possible to translate neuroanatomical pathways identified in animal studies to panic disorder in humans.Therefore,in this review we first present a basic overview of panic disorder in humans including the main subtypes,models commonly used to trigger panic attacks,related hypotheses,the neurotransmitter systems that may be involved,and the current clinical treatments to give the reader a comprehensive understanding of panic disorder.The animal section introduces the models that trigger panic-like behavior in animals and the brain regions that may be involved,providing insights for future elucidation of the neural circuit mechanisms behind panic attacks.

关 键 词：Panic disorder Panic attack Defense responses Animal studies Humans 

分 类 号：Q42[生物学—神经生物学]