黄芪汤治疗肝硬化及其相关并发症研究进展  

Huangqi Decoction in the Treatment of Cirrhosis and Its Related Complications:A Review

作　　者：徐文施 蒋式骊[1] 张华[1] XU Wenshi;JIANG Shili;ZHANG Hua(Institute of Liver Diseases&Key Laboratory of Liver and Kidney Diseases of Ministry of Education&Shanghai Key Laboratory of Traditional Chinese Clinical Medicine,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)

机构地区：[1]上海中医药大学附属曙光医院,上海中医药大学肝病研究所,肝肾疾病病证教育部重点实验室,上海市中医临床重点实验室,上海201203

出　　处：《世界中医药》2024年第13期2018-2022,2029,共6页World Chinese Medicine

基　　金：国家“十二五”重大新药创制《创新药物研究开发技术平台建设》项目(2012ZX09303009-001);国家自然科学基金项目(81603532);上海市科委“科技创新行动计划”临床医学领域科技支撑项目(19401972600)。

摘　　要：黄芪汤(黄芪、甘草)始载于《太平惠民和剂局方》,具有补中、益气、生津之效,治疗诸虚不足。黄芪汤为中医经典名方,临床广泛应用于多种辨证属虚损不足的疾病与证候。前期临床观察和实验研究证实,黄芪汤可显著提高肝脏的合成能力,有效延缓肝纤维化和肝硬化进展,并改善肝硬化门脉高压等相关并发症。故就黄芪汤全方、组分及其有效成分在抗肝纤维化,防治肝硬化及其并发症的基础和临床研究进展作一综述。Huangqi Decoction(Astragali Radix and Glycyrrhizae Radix et Rhizoma),first recorded in the Formulary of the Bureau of Taiping People′s Welfare Pharmacy(Tai Ping Hui Min He Ji Ju Fang),is known for its functions of tonifying the middle,benefiting qi,and generating fluids,and is used to treat various forms of deficiency.As a classic formula in traditional Chinese medicine(TCM),Huangqi Decoction is widely applied in clinical practice for treating a range of diseases and syndromes characterized by deficiency based on syndrome differentiation.Previous clinical observations and experimental studies have confirmed that Huangqi Decoction can significantly enhance the synthetic capacity of the liver,effectively delay the progression of liver fibrosis and cirrhosis,and improve complications related to portal hypertension caused by liver cirrhosis.This review aimed to summarize the progress in basic and clinical research on Huangqi Decoction,including its whole formula,individual components,and active ingredients,in relation to its anti-fibrotic effects and its role in the prevention and treatment of liver cirrhosis and its complications.

关 键 词：黄芪汤 皂苷成分 黄酮成分 肝纤维化 肝硬化 门脉高压 研究进展 综述 

分 类 号：R259[医药卫生—中西医结合]