肥大细胞在哮喘发生发展中的作用机制及中医药调控作用  

Mechanism of Mast Cells in Pathogenesis of Asthma and Regulatory Effect of Traditional Chinese Medicine

作　　者：刘珈含[1] 袁星星[1,2] 吕健 安妮玛·纳西姆 杨炳友 LIU Jiahan;YUAN Xingxing;LYU Jian;Anam Naseem;YANG Bingyou(Heilongjiang University of Chinese Medicine,Harbin 150040,China;Heilongjiang Academy of Chinese Medicine Sciences,Harbin 150036,China;The First Affiliated Hospital of Harbin Medical University,Harbin 150007,China;University of Agriculture Faisalabad,Faisalabad 38000,Pakistan)

机构地区：[1]黑龙江中医药大学,哈尔滨150040 [2]黑龙江省中医药科学院,哈尔滨150036 [3]哈尔滨医科大学附属第一医院,哈尔滨150007 [4]费萨拉巴德农业大学,费萨拉巴德38000

出　　处：《世界中医药》2024年第14期2203-2211,共9页World Chinese Medicine

基　　金：国家自然科学基金青年科学基金项目(82205007);黑龙江省“头雁”团队项目([2019]5号);黑龙江省“双一流”学科协同创新成果建设项目(LJGXCG2022-096)。

摘　　要：哮喘在中医学中属于哮病、喘症的范畴,是以气道平滑肌收缩、免疫细胞浸润和气道重塑等为特征的气道炎症疾病。肥大细胞为非特异性免疫细胞,在哮喘的形成和发展中扮演关键角色。中医药对哮喘的防治具有独特优势,但具体机制尚不明确。通过对相关研究综述后发现,肥大细胞活化后释放的组胺、蛋白酶、细胞因子等介质在哮喘气道损伤及重塑的病理过程中起重要作用。此外,中药复方制剂、单味中药及其活性成分、中成药及中医外治法等中医药方法可通过调节肥大细胞活化,抑制多种炎症介质和细胞因子的表达,进而发挥对哮喘的治疗作用。Asthma belongs to the category of wheezing disease in traditional Chinese medicine(TCM).It is an inflammatory disease of the airways characterized by smooth muscle contraction of airways,immune cell infiltration,and airway remodeling.Mast cells are non-specific immune cells that play a key role in the formation and development of asthma.TCM has unique advantages in the prevention and treatment of asthma,but the specific mechanism is not yet clear.After reviewing relevant research,it was found that mediators such as histamine,protease,and cytokines released after the activation of mast cells play an important role in the pathological process of airway injury and remodeling in asthma.In addition,TCM methods such as compound Chinese medicine preparations,single Chinese medicine and its active ingredients,traditional Chinese patent medicines,and external treatment of TCM can play a therapeutic role in asthma by regulating mast cell activation and inhibiting the expression of various inflammatory mediators and cytokines.

关 键 词：支气管哮喘 肥大细胞 中医药 气道慢性炎症反应 气道损伤 气道重塑 免疫细胞 生物活性介质 

分 类 号：R256.12[医药卫生—中医内科学]