人乳头瘤病毒疫苗接种后引起严重湿疹1例并文献复习  

Literature review of 1 case of severe eczema caused by human papillomavirus vaccine

作　　者：裴志超 李宏 沈鑫 孟祥飞 PEI Zhi-chao;LI Hong;SHEN Xin;MENG Xiang-fei(Zhejiang Provincial Center for Disease Control and Prevention,Hangzhou,Zhejiang 310051,China;不详)

机构地区：[1]浙江省疾病预防控制中心微生物所,浙江杭州310051 [2]中部战区疾病预防控制中心,北京100042 [3]宿迁市第一人民医院医学检验科,江苏宿迁223800

出　　处：《中华医院感染学杂志》2024年第14期2144-2148,共5页Chinese Journal of Nosocomiology

基　　金：浙江省基础公益研究计划基金资助项目(LQ24C010001)。

摘　　要：目的通过1例接种4v人乳头瘤病毒(HPV)疫苗后引起全身性急性湿疹患者的诊治情况,探讨接种HPV疫苗引起的不良反应以及HPV疫苗的安全性.方法某女性患者因全身性湿疹伴感染于2022年3月至宿迁市第一人民医院就诊,收集该患者临床资料,采用回顾性描述方法分析总结患者接种HPV疫苗后的病情变化、实验室检查资料与治疗方案,判定疾病诊断,探讨HPV疫苗的安全性以及引起的不良反应.结果患者女,30岁,全身出现密集的黄豆大小斑丘疹、丘疱疹和水疱,皮疹泛红,部分表面有明显的渗出液、糜烂结痂,耳后、面部、手、足、四肢以及躯干呈对称性分布.患者自觉瘙痒难忍,抓挠后引起感染,皮损处出现脓疱、脓痂.患者主诉:采用3针剂方法接种4v HPV疫苗,初次接种全身瘙痒,出现粟粒大小的红疹;接种第2和3剂出现黄豆大小的丘疹和水疱,皮肤损伤进行性加重.结合病史和皮肤损伤诊断为:HPV疫苗接种引起的急性湿疹.结论本研究在国内首次报告1例接种HPV疫苗引起湿疹的病例,为HPV疫苗安全性评估提供有效证据,并为临床诊断和研究提供参考.OBJECTIVE To investigate the diagnosis and treatment of 1 patient with 4v human papillomavirus(HPV)vaccine-induced systemic acute eczema and explore the adverse reactions caused by the HPV vaccine and the safety of the vaccine.METHODS A female patient was admitted to Suqian First People's Hospital due to sys-temic eczema complicated with infection in Mar,2022.The clinical data were collected from the patient,the change of illness condition,data of laboratory test and treatment plans were observed and summarized by retro-spective description method after the vaccination of HPV vaccine.The diagnosis of disease was determined,and the safety of HPV vaccine and the induced adverse reactions were explored.RESULTS The patient,female,30 years old,was presented with systemic dense soybean-sized spots,papules and blisters,with rash redness,exu-dates,erosion,and scabs on some surfaces.The rash was symmetrically distributed behind the ear,on the face,hands,feet,limbs and trunk.The patient felt unbearable itching,and pus and scabs appeared in some infected le-sion sites after scratching.The chief complaint:the patient received the vaccination of 4v HPV vaccine by 3 injec-tions,experienced generalized pruritus and a red miliary rash after the first injection,and developed to soybean-sized papules and blisters after the second and third injections,and the skin lesions became progressively worse.The patient was finally diagnosed with HPV vaccine-induced acute eczema on the basis of medical history and skin lesions.CONCLUSION It is reported for the first time in China that 1 case has the eczema caused by the HPV vac-cine,which may provide valid evidence for assessment of safety of HPV vaccine and reference for clinical diagnosis and research.

关 键 词：人乳头瘤病毒疫苗 接种 不良反应 湿疹 超敏反应 

分 类 号：R758.23[医药卫生—皮肤病学与性病学]