产褥感染病原菌和血清TAC、α1-AG、IL-35、IL-6表达及与感染程度的关系  

Pathogens and expressions of serum TAC,α1-AG,IL-35 and IL-6 in puerpera with puerperal infections and association with severity of infections

作　　者：白东燕[1] 吴玉[1] 张澍[1] BAI Dong-yan;WU Yu;ZHANG Shu(Nanyang Central Hospital/Nanyang Maternal and Child Health Hospital,Nanyang,Henan 473000,China)

机构地区：[1]南阳市中心医院南阳市妇幼保健院产科二病区,河南南阳473000

出　　处：《中华医院感染学杂志》2024年第14期2206-2210,共5页Chinese Journal of Nosocomiology

基　　金：河南省医学科技攻关基金资助项目(20024100)。

摘　　要：目的 探讨产褥感染血清总抗氧化能力(TAC)、α1酸性糖蛋白(α1-AG)、白细胞介素(IL)-35、IL-6表达及与感染程度的关系.方法 选取2022年6月-2023年6月南阳市中心医院及南阳市妇幼保健院产褥感染患者71例为感染组,另选取同期无产褥感染的产妇71例为对照组.对产褥感染患者宫颈分泌物进行病原菌检测,并检测所有纳入对象血清TAC、α1-AG、IL-35、IL-6水平,分析不同产褥感染严重程度、不同产褥感染部位患者血清TAC、α1-AG、IL-35、IL-6水平变化.结果 相较于对照组,感染组血清TAC水平降低,α1-AG、IL-35、IL-6水平升高(P<0.05);产褥感染主要病原菌为人型支原体(32.39%);不同感染程度患者血清学指标比较,差异有统计学意义(P<0.05),且不同感染程度血清TAC水平比较为轻度>中度>重度,血清α1-AG、IL-35、IL-6水平比较为轻度<中度<重度(P<0.05);不同产褥感染部位患者血清TAC、α1-AG、IL-35、IL-6水平比较,差异有统计学意义(P<0.05).结论 血清TAC、α1-AG、IL-35、IL-6与产褥感染的发生发展密切相关,临床可在产褥期监测以上血清学指标防治产褥感染.OBJECTIVE To explore the pathogens and expressions of serum total antioxidant capacity(TAC),α1-a-cidic glycoprotein(α1-AG),interleukin(IL)-35 and IL-6 in the puerpera with puerperal infections and analyze the association with severity of the infections.METHODS A total of 71 puerpera with puerperal infections who were treated in Nanyang Central Hospital/Nanyang Maternal and Child Health Hospital from Jun 2022 to Jun 2023 were assigned as the infection group,meanwhile,71 puerpera without puerperal infections were chosen as the con-trol group.Pathogens were isolated from the cervical secretions of the patients with puerperal infections,the levels of serum TAC,α1-AG,IL-35 and IL-6 were detected for all the enrolled subjects.The levels of serum TAC,α1-AG,IL-35 and IL-6 were observed and compared among the patients with different severities of puerperal infec-tions and different sites of puerperal infections.RESULTS The serum TAC level of the infection group was signifi-cantly lower than that of the control group,while the levels ofα1-AG,IL-35 and IL-6 of the infection group were significantly higher than those of the control group(P<0.05).Mycoplasma hom inis was the predominant species of pathogens,accounting for 32.39%.There were significant differences in the serologic indexes among the pa-tients with different severities of infections(P<0.05);as compared with the serum TAC level,it was the patients with mild infection>the patients with moderate infection>the patients with severe infection;as compared with the levels of serumα1-AG,IL-35 and IL-6,it was the patients with mild infection<the patients with moderate infection<the patients with severe infection(P<0.05).There were significant differences in the levels of serum TAC,α1-AG,IL-35 and IL-6 among the patients with different sites of puerperal infections(P<0.05).CONCLUSION The serum TAC,α1-AG,IL-35 and IL-6 are closely associated with genesis and progression of the puerperal infection.It is necessary for the hospital to monitor the above serological index

关 键 词：产褥感染 总抗氧化能力 Α1酸性糖蛋白 白细胞介素-35 白细胞介素-6 感染程度 病原菌 

分 类 号：R714.62[医药卫生—妇产科学]