地舒单抗注射液配合运动干预治疗老年绝经后骨质疏松症的研究  

Study of Disumab Injection Combined with Exercise Intervention in the Treatment of Senile Postmenopausal Osteoporosis

作　　者：项春林 XIANG Chunin(Department of Orthopedics,Liuhe District People's Hospital,Nanjing,Jiangsu Province,211500 China)

机构地区：[1]江苏省南京市六合区人民医院骨科,江苏南京211500

出　　处：《系统医学》2024年第11期77-79,90,共4页Systems Medicine

摘　　要：目的 分析地舒单抗注射液配合运动干预治疗老年绝经后骨质疏松症(Postmenopausal Osteoporosis,PMO)的效果。方法 选取2019年1月—2023年3月江苏省南京市六合区人民医院收治的60例老年PMO患者为研究对象,按照随机数表法分为两组,对照组、观察组各30例,对照组行运动干预,观察组在对照组基础上结合地舒单抗注射液治疗,对比两组治疗效果、骨代谢指标[骨钙素(Osteocalcin, OC)、Ⅰ型原胶原N-端前肽(Precollagen TypeⅠN-terminal Propeptide, PINP)、骨碱性磷酸酶(Bone Alkaline Phosphatase, BALP)]、膝关节功能(Lysholm膝关节评分)、疼痛评分(Visual Analogue Scale, VAS)。结果 观察组治疗总有效率(96.67%)相较于对照组(73.33%)更高,差异有统计学意义(χ^(2)=4.705,P<0.05);治疗后,观察组OC水平更高,PINP、BALP水平均更低,差异有统计学意义(P均<0.05);治疗后,观察组Lysholm膝关节评分更高,VAS评分更低,差异有统计学意义(P均<0.05)。结论 地舒单抗注射液+运动干预治疗老年PMO患者的效果较好,可改善骨代谢指标,改善膝关节功能,降低疼痛程度。Objective To analyze the effect of disumab injection combined with exercise intervention in the treatment of senile postmenopausal osteoporosis(PMO).Methods 60 elderly PMO patients admitted to Liuhe District People's Hospital of Nanjing,Jiangsu Province from January 2019 to March 2023 were selected as the study objects and were divided into two groups according to random number table method,with thirty cases in each control group and observa-tion group.The control group received exercise intervention,and the observation group was treated with disumab injec-tion on the basis of the control group.The therapeutic effects of the two groups were compared,including bone metabo-lism indexes[osteocalcin(OC),precollagen typeⅠN-terminal propeptide(PINP),bone alkaline phosphatase(BALP)],knee joint function(Lysholm knee joint score)and Visual Analogue Scale(VAS).Results The total effective rate of the observation group(96.67%)was higher than that of the control group(73.33%),and the difference was sta-tistically significant(χ^(2)=4.705,P<0.05).After treatment,OC level in observation group was higher,PINP and BALP levels were lower,and the differences were statistically significant(all P<0.05).After treatment,Lysholm knee joint scores were higher and VAS scores were lower in the observation group,and the differences were statistically signifi-cant(both P<0.05).Conclusion Disumab injection combined with exercise intervention has a good effect in the treat-ment of elderly patients with PMO,which can improve bone metabolism indexes,improve knee joint function and re-duce pain degree.

关 键 词：地舒单抗 运动干预 绝经后骨质疏松症 骨钙素 骨碱性磷酸酶 

分 类 号：R68[医药卫生—骨科学]