贝前列素钠治疗糖尿病肾病患者的临床研究  

Clinical Study on the Treatment of Diabetic Nephropathy with Beprost Sodium

作　　者：贾海萍 沈建松 贾婧 JIA Haiping;SHEN Jiansong;JIA Jing(Department of Nephrology,Yancheng First Hospital of Nanjing University School of Medicine(Yancheng First People's Hospital),Yancheng,Jiangsu Province,224000 China)

机构地区：[1]南京大学医学院盐城第一医院(盐城市第一人民医院)肾内科,江苏盐城224000

出　　处：《系统医学》2024年第11期84-86,97,共4页Systems Medicine

摘　　要：目的 分析贝前列素钠片对糖尿病肾病患者的治疗效果。方法 选取盐城市第一人民医院于2022年1月—2023年12月收治的100例糖尿病肾病患者为研究对象,应用奇偶分组法分为研究组和对照组,各50例。对照组采用常规治疗,研究组在常规治疗的基础上加用贝前列素钠片治疗。比较两组患者治疗后的临床疗效,治疗前后炎症反应及肾功能指标等。结果 研究组治疗总有效率(96.00%)高于对照组(72.00%),差异有统计学意义(χ^(2)=5.358,P<0.05);治疗后,两组白细胞介素-6、白细胞介素-1β水平均较治疗前降低,且研究组低于对照组,差异有统计学意义(P均<0.05);治疗后,研究组血肌酐、血尿素氮、24 h尿蛋白定量均优于对照组,差异有统计学意义(P均<0.05)。结论 贝前列素钠治疗糖尿病肾病的疗效显著,可以改善相关指标,提高肾脏功能。Objective To analyze the therapeutic effect of beprost sodium tablets on diabetic nephropathy patients.Methods A total of 100 diabetic nephropathy patients admitted to Yancheng First People's Hospital from January 2022 to December 2023 were selected as the study objects,and were divided into study group and control group by odd-even grouping method,with 50 cases in each group.The control group received conventional treatment,and the study group was treated with beprost sodium tablets on the basis of conventional treatment.The clinical efficacy,in-flammation and renal function indexes before and after treatment were compared between the two groups.Results The total effective rate of the study group(96.00%)was higher than that of the control group(72.00%),and the difference was statistically significant(χ^(2)=5.358,P<0.05).After treatment,the levels of interleukin-6 and interleukin-1βin two groups were lower than before treatment,and the study group was lower than the control group,the difference was sta-tistically significant(all P<0.05).After treatment,serum creatinine,blood urea nitrogen and 24 h urinary protein in the study group were better than those in the control group,and the differences were statistically significant(all P<0.05).Conclusion The efficacy of beprost sodium in the treatment of diabetic nephropathy is significant,which can improve the related indexes and improve the kidney function.

关 键 词：贝前列素钠 糖尿病肾病 临床研究 

分 类 号：R587[医药卫生—内分泌]