超早期溶栓对ASTEMI患者溶栓成功再通率、心脏不良事件及生活质量的影响  

Impact of Ultra-early Thrombolysis on Successful Recanalization Rate of Thrombolysis,Adverse Cardiac Events and Quality of Life in ASTEMI Patients

作　　者：于清 戚慧 李路 YU Qing;QI Hui;LI Lu(Department of Internal Medicine Ⅱ,Zaozhuang Shizhong District People's Hospital,Zaozhuang,Shandong Province,277100 China;Department of Functional Examination,Zaozhuang Municipal Hospital,Zaozhuang,Shandong Province,277100 China)

机构地区：[1]山东省枣庄市市中区人民医院内二科,山东枣庄277100 [2]山东省枣庄市立医院功能检查科,山东枣庄277100

出　　处：《系统医学》2024年第11期94-97,共4页Systems Medicine

摘　　要：目的 观察超早期溶栓对急性ST段抬高型心肌梗死(Acute ST-segment ElevationMyocardial Infarction,ASTEMI)患者溶栓成功再通率、心脏不良事件及生活质量的影响。方法 回顾性选取2020年1月—2022年12月山东省枣庄市市中区人民医院收治的78例ASTEMI患者的临床资料,根据急性心肌梗死症状出现至溶栓治疗的时间,将患者分为两个组,即超早期(<3 h)溶栓组(观察组)和非超早期(3~12 h)溶栓组(对照组),各39例,溶栓治疗后比较两组患者的溶栓成功再通率、心脏不良事件发生率及生活质量评分。结果 观察组溶栓成功再通率为82.05%,而对照组仅为61.53%,差异有统计学意义(χ^(2)=4.052,P<0.05);观察组心脏不良事件发生率为5.13%,明显低于对照组的20.51%,差异有统计学意义(χ^(2)=4.129,P<0.05);观察组生活质量各维度评分均高于对照组,差异有统计学意义(P均<0.05)。结论 超早期溶栓的实施提高急性ST段抬高型心肌梗死患者溶栓成功再通率,减少心脏不良事件的发生,改善患者生活质量。Objective To observe the effects of ultra-early thrombolysis on the successful recanalization rate of throm-bolysis,adverse cardiac events,and quality of life in patients with acute ST-segment elevation myocardial infarction(ASTEMI).Methods The dinical data of Seventy-eight patients with ASTEMI admitted to Zaozhuang Shizhong Dis-trict People's Hospital from January 2020 to December 2022 were retrospectively selected.According to the time from the appearance of acute myocardial infarction symptoms to thrombolytic therapy,the patients were divided into two groups:the ultra-early(<3 h)thrombolysis group(observation group)and the non-ultra-early(3-12 h)thrombolysis group(control group),each with 39 cases.After thrombolytic treatment,the successful recanalization rate of thromboly-sis,the incidence of adverse cardiac events and the quality of life scores of patients in the two groups were compared.Results The successful recanalization rate of thrombolysis in the observation group was 82.05%,while that of the con-trol group was only 61.53%,and the difference was statistically significant(χ^(2)=4.052,P<0.05).The incidence rate of adverse cardiac events in the observation group was 5.13%,which was significantly lower than the 20.51%in the con-trol group,and the difference was statistically significant(χ^(2)=4.129,P<0.05).The scores of all dimensions of quality of life in the observation group were higher than those in the control group,and the differences were statistically sig-nificant(all P<0.05).Conclusion The implementation of ultra-early thrombolysis improves the successful recanaliza-tion rate of thrombolysis in patients with acute ST-segment elevation myocardial infarction,reduces the incidence of adverse cardiac events,and improves the quality of life of patients.

关 键 词：急性ST段抬高型心肌梗死 静脉溶栓治疗 超早期溶栓 心脏不良事件 生活质量 

分 类 号：R542[医药卫生—心血管疾病]