大剂量静脉注射免疫球蛋白治疗小儿重症病毒性脑炎的临床价值  

Clinical Value of High-dose Intravenous Immunoglobulin in the Treatment of Pediatric Severe Viral Encephalitis

作　　者：易华 YI Hua(Yongzhou Central Hospital,Yongzhou,Hunan Province,425000 China)

机构地区：[1]永州市中心医院,湖南永州425000

出　　处：《系统医学》2024年第11期131-134,共4页Systems Medicine

摘　　要：目的 探究大剂量静注免疫球蛋白对小儿重症病毒性脑炎的治疗效果。方法 选取2019年1月—2023年12月永州市中心医院收治的54例重症病毒性脑炎患儿为研究对象,以奇偶数分为两组,各27例。对照组、观察组分别行小剂量、大剂量静脉注射免疫球蛋白治疗,比较治疗效果。结果 观察组高热消失时间、头痛消失时间、呕吐消失时间、惊厥消失时间、昏迷消失时间、住院时间均短于对照组,差异有统计学意义(P均<0.05)。观察组患儿脑电图恢复正常时间(7.53±1.49)d、脑脊液恢复正常时间(8.13±1.66)d均短于对照组(9.68±1.76)、(11.29±1.80)d,差异有统计学意义(t=4.845、6.706,P均<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论 大剂量静脉注射免疫球蛋白,可以使重症病毒性脑炎患儿的临床症状显著好转,保护患儿的神经功能,具有一定的安全性,效果显著。Objective To explore the therapeutic effect of high-dose intravenous immunoglobulin on pediatric severe viral encephalitis.Methods Fifty-four cases of children with severe viral encephalitis admitted to Yongzhou Central Hospital from January 2019 to December 2023 were selected as the study subjects,and were divided into two groups of 27 cases each by odd-even number.The control group and the observation group were treated with small-dose and high-dose intravenous immunoglobulin,respectively,compared the therapeutic effects.Results In the observation group,the disappearance time of high fever,headache,vomiting,convulsions,coma and hospitalization were shorter than those of the control group,and the differences were statistically significant(all P<0.05).The time for the EEG to return to normal(7.53±1.49)d and the time for the cerebrospinal fluid to return to normal(8.13±1.66)d of the chil-dren in the observation group were shorter than those of the control group(9.68±1.76)d and(11.29±1.80)d,and the differences were statistically significant(t=4.845,6.706,both P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion High-dose intravenous immuno-globulin can make the clinical symptoms of children with severe viral encephalitis improve significantly and protect the neurological function of the children,which is safe and effective.

关 键 词：大剂量 静脉注射用免疫球蛋白 小儿重症病毒性脑炎 神经功能 

分 类 号：R725[医药卫生—儿科]