Eph受体家族信号转导途径及其在机体固有免疫反应中的作用  

Research progress on the involvement of Eph receptor family signaling pathways in innate immunity responses in the body

作　　者：董春旭(综述) 朱国强 黄立(审校)[2] DONG Chunxu;ZHU Guoqiang;HUANG Li(Ophthalmology Department,School of Clinical Medicine,Jining Medical University,Jining 272013,Shandong Province,China;不详)

机构地区：[1]济宁医学院临床医学院眼科,山东济宁272013 [2]济宁医学院附属医院眼科,山东济宁272029

出　　处：《微生物学免疫学进展》2024年第3期91-96,共6页Progress In Microbiology and Immunology

基　　金：山东省自然科学青年基金(ZR2020QH149)。

摘　　要：促红细胞生成素肝细胞激酶(erythropoietin-producing hepatocyte-kinase, Eph)受体家族作为已知最大的酪氨酸激酶受体(receptor tyrosine kinase, RTK)家族之一,在机体生理功能调控和多种疾病的发生、发展中发挥重要作用。固有免疫作为机体免疫系统抵抗外来病原体感染的第一道防线,通过多种方式发挥抵抗病原体的作用。目前已知Eph受体家族中的多种成员参与固有免疫进程,通过不同信号通路途径影响疾病的发生、发展及转归。进一步深入研究Eph受体家族信号转导途径在机体固有免疫反应中的作用,能够更好地为相关疾病的发生与进展提供理论依据。The erythropoietin-producing hepatocyte-kinase(Eph)receptor family,as the largest family known to receptor tyrosine kinases(RTKs),plays an important role in the regulation of the body's physiological functions and in the development of a variety of diseases.Accumulating evidences have revealed that multiple members in the Eph receptor family are involved in innate immunity process,the first line of host defense against invading pathogens,contributing to disease onset,progression and regression via diverse signaling pathways.Thus,continuing to drive further studies on the role of Eph receptors signaling pathways in innate immune response will allow for better prevention,diagnosis and treatment of related clinical diseases.

关 键 词：促红细胞生成素肝细胞激酶受体 固有免疫 信号转导通路 

分 类 号：R393.2[医药卫生—基础医学]