比色法适配体传感器在抗生素检测中的研究进展  

Advances in antibiotics detection based on colorimetric aptasensors

作　　者：高羽菲 甄建辉 赵杰 张玉萍[5] 潘立刚[3,4] 梁刚 李再兴[1,6] GAO Yufei;ZHEN Jianhui;ZHAO Jie;ZHANG Yuping;PAN Ligang;LIANG Gang;LI Zaixing(College of Environmental Science and Engineering,Hebei University of Science and Technology,Shijiazhuang,050000,China;Shijiazhuang Customs Technology Center,PRC,Shijiazhuang 050000,China;Institute of Quality Standard and Testing Technology,BAAFS(Beijing Academy of Agriculture and Forestry Sciences),Beijing 100097,China;Risk Assessment Lab for Agro-products(Beijing),Beijing 100097,China;Library of Hebei University of Science and Technology,Shijiazhuang 050000,China;Department of Environmental Engineering,Beijing Institute of Petrochemical Technology,Beijing 102617,China)

机构地区：[1]河北科技大学环境科学与工程学院,石家庄050000 [2]石家庄海关技术中心,石家庄050000 [3]北京市农林科学院质量标准与检测技术研究所,北京100097 [4]农业部农产品质量安全风险评估实验室(北京),北京100097 [5]河北科技大学图书馆,石家庄050000 [6]北京石油化工学院环境工程系,北京102617

出　　处：《分析试验室》2024年第7期1064-1072,共9页Chinese Journal of Analysis Laboratory

基　　金：河北省重点研究计划项目(21326610D,20325502D);北京市自然科学基金(L182031);国家自然科学基金青年基金(21806013)资助。

摘　　要：医疗及养殖业中抗生素的过量使用给生态环境和人类健康带来了严重危害。与传统的色谱及光谱检测方法相比,适配体生物传感技术作为一种较为新颖的检测方法备受青睐和关注,特别是比色法具有简单、灵敏、快速、可视化等诸多优势,被广泛用于抗生素检测。本文介绍了适配体的概念、比色法传感原理,重点综述了近年来不同种类抗生素比色法适配体生物传感器的研究进展,并对比色适配体传感器的发展趋势进行了展望。The overuse of antibiotics in the medical and breeding industries has brought serious harm to the ecological environment and human health.Compared with the traditional chromatographic and spectral methods,the aptamer biosensing technology,as a novel detection method,has attracted much attentions.In particular,colorimetric method has many advantages such as simplicity,sensitivity,rapidity and visualization.Therefore,the colorimetric aptamer biosensing technology has been widely used for antibiotic detection.This paper first discusses the concept of aptamer and sensing principle,and then focuses on the recent progress of different kinds of antibiotic colorimetric aptamer biosensors.Finally,the development trend of color aptamer sensors are prospected.

关 键 词：抗生素 检测 比色法 适配体 生物传感器 

分 类 号：TP212[自动化与计算机技术—检测技术与自动化装置]