普通球囊与药物涂层球囊治疗ASO支架内再狭窄的近期疗效对照  

Comparison of short-term efficacy between conventional balloon and drug-coated balloon in the treatment of restenosis within ASO stents

作　　者：苏宇鹏 贺清明[1] SU Yu-peng(Yan’an University School of Medicine,Yan’an 716000,Shanxi,China)

机构地区：[1]延安大学医学院,陕西延安716000

出　　处：《牡丹江医学院学报》2024年第4期49-52,136,共5页Journal of Mudanjiang Medical University

摘　　要：目的探讨普通球囊与药物涂层球囊(drug coated balloon,DCB)治疗下肢动脉硬化闭塞症(arteriosclerosis obliterans,ASO)支架内再狭窄的近期疗效对照。方法选择2021年1月至2022年12月我院收治的下肢动脉硬化闭塞症支架再狭窄患者90例作为研究对象,按照不同治疗方案分为普通组(45例,非顺应性后扩球囊普通球囊治疗)与药物涂层组(45例,药物涂层球囊治疗),观察两组术前、术后12 h、7 d时血管内皮功能[P选择素、一氧化氮(nitric oxide,NO)、内皮素-1(endothelin-1,ET-1)]水平;比较两组术前、术后6个月、术后12个月Rutherford分级及踝肱指数(ankle brachial index,ABI)及术后6个月、12个月靶向血管畅通情况。结果术后12 h、7 d,两组P选择素、ET-1水平高于术前,NO水平低于术前(P<0.05);而药物涂层组P选择素、ET-1水平低于普通组(P<0.05),而NO水平低于普通组(P<0.05);术后6个月、12个月Ruthweford分级低于术前(P<0.05);而药物涂层组Rutherford分级低于普通组,差异有统计学意义(P<0.05);术后3d、术后6个月、12个月两组ABI值高于术前(P<0.05);术后6个月、12个月药物涂层组ABI值高于普通组,差异有统计学意义(P<0.05);术后6个月、12个月药物涂层组靶向血管通畅率高于普通组(P<0.05),药物涂层组CD-TLR低于普通组,差异有统计学意义(P<0.05)。结论药物涂层球囊治疗可减少对患者血管内皮功能的损伤,改善患者下肢缺血症,维持靶向血管通畅。Objective To explore the short-term efficacy of conventional balloon and drug-coated balloon(DCB)in the treatment of stent restenosis in lower limb arteriosclerosis obliterans(ASO).Methods Ninety patients with lower limb arteriosclerosis occlusive stent restenosis admitted to our hospital from January 2021 to December 2022 were selected and divided into a common group(45 cases,non-compliant posterior balloon conventional balloon treatment)and a drug-coated group(45 cases,drug-coated balloon treatment)according to different treatment plans.The levels of vascular endothelial function[P-selectin,nitric oxide(NO),and endothelin-1(ET-1)]were observed before surgery,12 hours,and 7 days after surgery.The Rutherford grading,ankle brachial index(ABI),and targeted vascular patency between the two groups at preoperative,postoperative 6 months and 12 months,were compared,respectively.Results At 12 hours and 7 days after surgery,the levels of P-selectin and ET-1 in both groups were higher than before surgery,while the levels of NO were lower than those before surgery(P<0.05);The levels of P-selectin and ET-1 in the drug-coated group were lower than those in the control group(P<0.05),while the levels of NO were lower than those in the control group(P<0.05);The Rutherford grading was lower than that before surgery at 6 and 12 months postoperatively(P<0.05);The Rutherford grading of the drug-coated group was lower than that of the control group,and the difference was statistically significant(P<0.05);The ABI values of the two groups were higher than those before surgery at 3 days,6 months,and 12 months after surgery(P<0.05);The ABI values of the drug-coated group were higher than those of the control group at 6 and 12 months after surgery,and the difference was statistically significant(P<0.05);At 6 and 12 months after surgery,the targeted vascular patency rate in the drug-coated group was higher than that in the control group(P<0.05),and the CD-TLR in the drug-coated group was lower than that in the control group,with statistic

关 键 词：下肢动脉硬化闭塞症 支架内再狭窄 普通球囊 药物涂层球囊 

分 类 号：R654.4[医药卫生—外科学]