度洛西汀联合胰激肽原酶对痛性糖尿病周围神经病变患者神经传导功能及氧化应激反应的影响  

Effects of duloxetine combined with pancreatic kininogenase on nerve conduction function and oxidative stress in patients with painful diabetic peripheral neuropathy

作　　者：李杰 赵伟[1] LI Jie(Nanyang Central Hospital,Nanyang 473000,Henan,China)

机构地区：[1]南阳市中心医院神经内科,河南南阳473000

出　　处：《牡丹江医学院学报》2024年第4期81-85,共5页Journal of Mudanjiang Medical University

摘　　要：目的探讨度洛西汀联合胰激肽原酶对痛性糖尿病周围神经病变(Painful diabetic peripheral neuropathy,PDPN)患者神经传导功能及氧化应激反应的影响。方法回顾性选取2021年6月至2023年6月本院收治的104例PDPN患者分为单一组(n=52)、联合组(n=52)。单一组予以胰激肽原酶治疗,联合组予以度洛西汀联合胰激肽原酶治疗。统计对比两组临床疗效及治疗前后临床症状评分、糖脂代谢、神经传导功能[感觉神经传导速度(Sensory nerve conduction velocity,SCV)、运动神经传导速度(Motor nerve conduction velocity,MCV)]、神经因子[神经生长因子(Neurogenic growth factor,NGF)、胰岛素样生长因子-1(Insulin like growth factor-1,IGF-1)、脑源性神经营养因子(Brain derived neurotrophic factor,BDNF)]、氧化应激[丙二醛(Malondialdehyde,MDA)、过氧化氢酶(Catalase,CAT)、超氧化物歧化酶(Superoxide dismutase,SOD)]水平。结果联合组总有效率86.54%,高于单一组69.23%(P<0.05);治疗后,联合组临床症状评分低于单一组(P<0.05);治疗后,联合组空腹血糖(Fasting blood glucose,FPG)、餐后2 h血糖(Postprandial 2-hour blood glucose,2hPG)、总胆固醇(Total cholesterol,TC)、三酰甘油(Triacylglycerol,TG)、低密度脂蛋白胆固醇(Low density lipoprotein cholesterol,LDL-C)水平低于单一组,腓总神经、正中神经的SCV、MCV高于单一组(P<0.05);治疗后,联合组血清NGF、IGF-1、BDNF水平高于单一组(P<0.05);治疗后,联合组血清MDA水平低于单一组,CAT、SOD水平高于单一组(P<0.05)。结论度洛西汀联合胰激肽原酶治疗PDPN的疗效确切,可改善临床症状、糖脂代谢、神经传导功能,促进周围神经功能恢复,增强机体抗氧化能力。Objective To investigate the effects of duloxetine combined with pancreatic kininogenase on nerve conduction function and oxidative stress in patients with painful diabetic peripheral neuropathy(PDPN).Methods A total of one hundred and four patients with PDPN treated in our hospital from June 2021 to June 2023 were retrospectively selected and divided into single group(n=52)and combined group(n=52).The single group was treated with pancreatic kininogenase,and the combination group was treated with duloxetine combined with pancreatic kininogenase.Compare the clinical efficacy of the two groups,as well as clinical symptom score,glucose and lipid metabolism,nerve conduction function[sensory nerve conduction velocity(SCV),motor nerve conduction velocity(MCV)],nerve factors[Neurogenic growth factor(NGF),insulin like growth factor(IGF-1),brain derived neurotrophic factor(BDNF)]and oxidative stress[Malondialdehyde(MDA),catalase(CAT),superoxide dismutase(SOD)]levels before and after treatment.Results The total effective rate of combination group was 86.54%,which was higher than that of single group 69.23%(P<0.05).After treatment,the clinical symptom score of the combined group was lower than that of the single group(P<0.05).After treatment,the fasting blood glucose(FPG),postprandial 2-hour blood glucose(2hPG),total cholesterol(TC),triacylglycerol(TG),and low density lipoprotein cholesterol(LDL-C)levels in the combined group were lower than those in the single group,and SCV and MCV in common peroneal nerve and median nerve were higher than those in single group(P<0.05).After treatment,the serum levels of NGF,IGF-1 and BDNF in combination group were higher than those in single group(P<0.05).After treatment,the serum MDA level of the combined group was lower than that of the single group,and the CAT and SOD levels were higher than that of the single group(P<0.05).Conclusion Duloxetine combined with pancreatic kininogenase is effective in the treatment of PDPN,which can improve clinical symptoms,glucose and lipid metabolism,

关 键 词：痛性糖尿病周围神经病变 度洛西汀 胰激肽原酶 氧化应激 神经传导功能 

分 类 号：R587.2[医药卫生—内分泌]