A crosstalk-free dual-mode sweat sensing system for naked-eye sweat loss quantification via changes in structural reflectance  

作　　者：Bowen Zhong Hao Xu Xiaokun Qin Lingchen Liu Hailong Wang Lili Wang 

机构地区：[1]State Key Laboratory for Superlattices and Microstructures,Institute of Semiconductors,Chinese Academy of Sciences,Beijing 100083,China [2]Center of Materials Science and Optoelectronic Engineering,University of Chinese Academy of Sciences,Beijing 100049,China

出　　处：《Bio-Design and Manufacturing》2024年第4期428-438,共11页生物设计与制造（英文）

基　　金：support from the National Natural Science Foundation of China(No.62174152)。

摘　　要：Sweat loss monitoring is important for understanding the body’s thermoregulation and hydration status,as well as for comprehensive sweat analysis.Despite recent advances,developing a low-cost,scalable,and universal method for the fabrication of colorimetric microfluidics designed for sweat loss monitoring remains challenging.In this study,we propose a novel laserengraved surface roughening strategy for various flexible substrates.This process permits the construction of microchannels that show distinct structural reflectance changes before and after sweat filling.By leveraging these unique optical properties,we have developed a fully laser-engraved microfluidic device for the quantification of naked-eye sweat loss.This sweat loss sensor is capable of a volume resolution of 0.5µL and a total volume capacity of 11µL,and can be customized to meet different performance requirements.Moreover,we report the development of a crosstalk-free dual-mode sweat microfluidic system that integrates an Ag/AgCl chloride sensor and a matching wireless measurement flexible printed circuit board.This integrated system enables the real-time monitoring of colorimetric sweat loss signals and potential ion concentration signals without crosstalk.Finally,we demonstrate the potential practical use of this microfluidic sweat loss sensor and its integrated system for sports medicine via on-body studies.

关 键 词：Sweat loss sensor Microfluidic design Structural reflectance Dual-mode integration Crosstalk-free 

分 类 号：TH789[机械工程—仪器科学与技术] TP212[机械工程—精密仪器及机械]