观察LISA技术联合NCPAP治疗新生儿呼吸窘迫综合征的有效性  

Effectiveness of LISA Technology Combined with NCPAP in the Treatment of Neonatal Respiratory Distress Syndrome

作　　者：孟靓靓[1] MENG Liangliang(Department of Pediatrics,Jining First People's Hospital,Jining 272000,Shandong,China)

机构地区：[1]济宁市第一人民医院儿科,山东济宁272000

出　　处：《中外医疗》2024年第17期29-32,45,共5页China & Foreign Medical Treatment

摘　　要：目的 分析新生儿呼吸窘迫综合征采取侵入性肺表面活性物质治疗(Less Invasive Surfactant Administration,LISA)技术联合经鼻持续气道正压(Transnasal Continuous Positive Airway Pressure,NCPAP)的有效性。方法 随机选取2021年4月—2023年6月济宁市第一人民医院儿科80例新生儿呼吸窘迫综合征患儿为研究对象,采取抽签法分为分析组和参照组,每组40例。分析组采取LISA技术联合NCPAP治疗,参照组采取气管插管肺表面活性物质灌注治疗,对比两组治疗效果。结果 治疗后,分析组治疗总有效率(95.00%)高于参照组(75.00%),差异有统计学意义(χ^(2)=6.274,P=0.012)。治疗后,分析组机械通气时间、住院时间、吸氧时间均短于参照组,差异有统计学意义(P均<0.05)。治疗后,分析组晚期氧化蛋白产物(Advanced Oxidation Protein Products,AOPPs)水平低于参照组,差异有统计学意义(P<0.05)。治疗后,分析组血气指标及肺循环功能指标均优于参照组,差异有统计学意义(P均<0.05)。分析组不良反应总发生率低于参照组,差异有统计学意义(P<0.05)。结论 LISA技术联合NCPAP治疗新生儿呼吸窘迫综合征有利于改善新生儿血氧指标,改善患儿肺功能循环,缩短新生儿机械通气时间,减少不良反应的发生。Objective To analyze the effectiveness of less invasive surfactant administration(LISA) combined with transnasal continuous positive airway pressure(NCPAP) for neonatal respiratory distress syndrome.Methods A total of eighty children with neonatal respiratory distress syndrome in the pediatrics department of Jining First People's Hospital from April 2021 to June 2023 were randomly selected as the study objects and divided into analysis group and reference group by drawing lots,with forty cases in each group.Analysis group was treated with LISA technology combined with NCPAP,and reference group was treated with tracheal intubation and pulmonary surfactant perfusion.The therapeutic effect of the two groups was compared.Results After treatment,the effective rate of the analysis group(95.00%) was higher than that of the reference group(75.00%),the difference was statistically significant(χ^(2)=6.274,P=0.012).After treatment,the mechanical ventilation time,hospitalization time and oxygen inhalation time in the analysis group were shorter than those in the reference group,and the differences were statistically significant(all P<0.05).After treatment,the level of advanced oxidation protein products(AOPPs) in analysis group was lower than that in reference group,and the difference was statistically significant(P<0.05).After treatment,blood gas indexes and pulmonary circulation function indexes in analysis group were better than those in reference group,and the differences were statistically significant(both P<0.05).The incidence of adverse reactions in analysis group was lower than that in reference group,and the difference was statistically significant(P<0.05).Conclusion LISA technology combined with NCPAP in the treatment of neonatal respiratory distress syndrome is beneficial to improve the blood oxygen index of newborns,improve the pulmonary functional circulation,shorten the mechanical ventilation time of newborns,and reduce the occurrence of adverse reactions.

关 键 词：LISA技术 新生儿呼吸窘迫综合征 NCPAP治疗 不良反应 

分 类 号：R4[医药卫生—临床医学]